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conferenceseries
.com
November 13-15, 2017 | Las Vegas, USA
14
th
International Conference and Exhibition on
Materials Science and Engineering
RRJOMS | Volume 5 | Issue 7 | November, 2017
NIR light-triggered, localized anti-cancer drug delivery using poly (ε-caprolactone) (PCL) fibers
incorporated with indocyanine green and phase-changeable fatty acid
Ju Hyang Park, Se Jeong Hwang, Hyun Jin Oh, Dong Choon Hyun
and
Dong Gug Kang
Kyungpook National University, Republic of Korea
T
his paper explains a new system for NIR light-triggered release of drugs. The system consists of poly(ε-caprolactone) (PCL)-based
fibers having a core loaded with doxorubicin (DOX) and a sheath incorporated with indocyanine green (ICG) as a NIR-absorbing
agent together with a phase-changeable fatty acid. Upon NIR irradiation, the photothermal agent will generate heat to raise the local
temperature of the fibers. When the temperature is above the melting point of the fatty acid, nano-pores will be produced in the
fibers. This response to NIR irradiation allows the instant release of DOX from the fibers through the pores, leading to the significant
enhancement of anticancer activity in combination with the hyperthermia effect arising from the photothermal agent.
Biography
Ju Hyang PARK is a first year doctoral course student in polymer science and engineering at kyungpook national university in republic of korea under professor Dong
Choon Hyun. She received her M.S. degree and her B.S. degree in polymer science and engineering from the same university. The topic of her PhD research is "smart
drug delivery system using electrospinning.
jh.park@knu.ac.krJu Hyang Park et al., Res. Rev. J Mat. Sci. 2017, 5:7
DOI: 10.4172/2321-6212-C1-012