15 / 28
Pathology 2018
Research & Reviews: Journal of Medical and Health Sciences
ISSN: 2319-9865
Page 70
October 08-09, 2018
Edinburgh, Scotland
17
th
International Conference on
Pathology & Cancer
Epidemiology
Introduction:
Diabetes mellitus is characterized by hyperglycemia
resulting from defects of insulin and is associated with long-
term damage of various organs. Glycated hemoglobin is widely
used as a gold standard for monitoring glycemic control over
the previous three months but it may be affected by genetic,
physiological, hematological and illness-related factors. Two
known factors which can modulate the glycation of proteins
are the prevailing concentration of glucose and the half life of
the proteins. Eventhough, HbA1c is a precise diagnostic tool for
diabetic patients there are different factors like iron deficiency
anemia (IDA) which can give false result of HbA1c.
Aim:
The aim is to study the effect of iron deficiency anemia on
levels of HbA1c in diabetic patients.
Methodology:
Fifty diabetic, iron deficient anaemic patients
(cases) and 50 age-matched diabetic patients (controls) were
enrolled. The patients with haemoglobinopathies, haemolytic
anaemia, chronic alcohol ingestion and chronic renal failure were
excluded. Haemato¬logic investigations, fasting glucose and
HbA1c levels were measured.
Results:
The mean HbA1c in cases was 7.91±1.20 and in controls
was 7.11±0.89, which was significant statistically as the p value
was 0.0003 (<0.05). There was a significant difference between
the values of hemoglobin between the cases and controls and no
difference between the fasting glucose levels.
Conclusion:
Iron deficiency anemia is the most prevalent
nutritional anemia in India. Our study showed that IDA spuriously
elevates HbA1C levels in the diabetic patients independent
of plasma glucose concentration. Hence, it is important to
exclude iron deficiency anemia and correct it before making any
diagnostic/ therapeutic decision in a patient of diabetes mellitus.
maroonnebula@gmail.comA study of the effect of iron deficiency anemia on HbA1c in
Diabetes
Manjot kaur gill
and
Arnav Roychoudhury
Adesh Institute of Medical Sciences & Research, India
RRJMHS 2018
Volume: 7