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Pathology 2018
Research & Reviews: Journal of Medical and Health Sciences
ISSN: 2319-9865
Page 30
October 08-09, 2018
Edinburgh, Scotland
17
th
International Conference on
Pathology & Cancer
Epidemiology
T
umors exhibit complex combinations of traits in association
with mutations in the genomes of their lineage committed
parent cells. Large numbers of mutations occur in tumors,
but the precise driver mutations for each tumors type remain
unclear. Some genome studies have documented some tumors
type specific patterns of mutation in protein coding genes.
However, most of these mutations appear to be passenger/
secondary genomic events. For tumors molecular pathology,
almost all genomic studies have been of protein coding
genes affecting growth, either via cell signaling pathways
or proliferation induction. Genes and mutations in them for
other traits in tumors have been relatively neglected. In recent
years, many regulatory non-coding (RNA) genes in various
classes have been described. Studies of the effects of their
mutations are in progress. The paper reviews data in the UCSC
Genome Browser concerning non-coding genes in or near
histopathologically significant and hereditarily predisposing
tumors genes. The potential effects of the type of mutation
affecting these genes are discussed.
Biography
Leon P Bignold is a Histopathologist interested in genomic mechanisms of
the histopathology and related features of tumors. He had published 18 pa-
pers, edited one volume “
Cancer: Cell Structures, Carcinogens and Genomic
Instability”
, Birkhäuser, of 2006 and wrote two books
“David Paul Hansem-
ann: Contributions to Oncology”
, Birkhäuser, 2008; “Principles of Tumors: a
Translational Approach to Foundations”, Elsevier 2015 in this area. His re-
search interests are genomic explanations of the histopathology and related
phenomena of tumors.
leon.bignold@adelaide.edu.auRegulatory RNA genes: could they be important to the
histopathology of tumors?
Leon P Bignold
University of Adelaide, South Australia
Leon P Bignold, RRJMHS 2018
Volume: 7