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Pathology 2018 Research & Reviews: Journal of Medical and Health Sciences
ISSN: 2319-9865 Page 53
October 08-09, 2018
Edinburgh, Scotland
17th International Conference on
Pathology & Cancer
Epidemiology
Assisted reproductive technologies (ART) are widely
used for the treatment of infertility. There are evidences,
which suggest that children born through ART have relatively
low IQ levels and the in vitro culture of embryos can alter
neurodevelopmental processes in the resulting offspring.
These findings raise the possibility that embryo culture alters
the expression of neurotrophins; factors that regulate the
development, survival and functions of neurons. Among these,
BDNF is a key molecule, which maintains synaptic plasticity,
survival of the hippocampal neurons and cognitive ability. The
aim of the present study was to determine whether embryo
culture affects the morphology of the dentate gyrus and the
expression of BDNF in the hippocampus. Analyses by qRT-PCR
and western blotting indicated no significant alterations in the
expression of BDNF or the thickness of dentate gyrus in our
mouse model.
Biography
Ayesha Maqbool has completed her PhD from University of Ulm, Ger-
many in 2013. She did Post doc from Adnan Menderes University, Aydin,
Turkey in 2016. At the moment she is working as Assistant Professor in
Virtual University of Pakistan. She is supervising eleven MS students in
the field of Biotechnology, Genetics and Zoology.
Effect of embryo culture on the expression of brain-derived
neurotrophic factor (BDNF) in the hippocampus
Ayesha Maqbool1, 2, Heba Salem3, Goksel Dogan2 and Levent Karagenc2
1Virtual University of Pakistan, Pakistan
2Adnan Menderes University, Turkey
3King Khalid University, Saudia Arabia
Ayesha Maqbool et al., RRJMHS 2018
Volume: 7