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Cancer Glycobiology

During the stage of cancer and tumor, some changes occur in glycan structure and glycosylation also. Like usual cells throughout embryogenesis, tumor cells undergo activation and rapid development, adhere to a kind of other cell types and cell matrices, and invade tissues. Embryonic development and cellular activation in vertebrates are normally escorted by changes in cellular glycosylation profiles. Therefore, it is not astonishing that glycosylation changes are furthermore a universal characteristic of malignant transformation and tumor progression. The soonest clues came from observing that vegetation lectins (e.g., wheat germ agglutinin) displayed enhanced binding to and agglutination of tumor units. 

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