Dental & Dental Hygiene 2018: Leukocyte and platelet-rich fibrin in orodental and maxillo-facial surgery: current evidence from randomized controlled clinical trials - Ziyad S Haidar - Universidad de los Andes

Abstract

 Background: Despite significant improvements in reconstruction techniques and materials during the last decades, the regeneration, restoration and/or repair of oro-dental and maxillo-facial defect remains a challenge. Platelet concentrates are autologous blood extracts obtained through centrifugation of whole blood samples. The preparation procedure allows the gathering and concentration of platelets and other therapeutic blood constituents (fibrinogen/fibrin, growth factors, leukocytes and circulating cells), in clinically-usable preparations (surgical adjuvants), which may enhance, accelerate and promote tissue (hard and soft) wound healing and regeneration. Despite promising clinical observations, their overall effectiveness remains debated, to date.