Department of Humanity Sciences, University of Science and Culture, Tehran, Iran
Received: 04-Mar-2023, Manuscript No. RCT-23- 92748; Editor assigned: 06- RCT -2023, PreQC No. RCT -23- 92748 (PQ); Reviewed: 20-Mar-2023, QC No. RCT -23- 92748; Revised: 27-Mar-2023, Manuscript No. RCT -23- 92748 (R); Published: 03-Apr-2023, DOI: 10.4172/Rep cancerTreat.7.1.002.
Citation: Cao N. Characteristics of Radiation Therapy and Gene Therapy. 2023;7: 002.
Copyright: © 2023 Cao N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Radiation therapy is a common treatment modality for cancer. Radiation therapy machines deliver high doses of radiation to cancerous cells, destroying them while sparing surrounding healthy cells. Several types of radiation therapy are available, such as external beam radiation therapy, brachytherapy, and stereotactic radiosurgery. It is a standard part of cancer treatment protocols and has been used to treat various cancers, including brain tumors. Characteristics of Radiation Therapy Radiation therapy works by damaging the DNA of cancer cells, making it difficult for them to multiply and divide further. The radiation energy disrupts the cancer cells' normal function, prompting them to undergo apoptosis. The treatment can be delivered externally or internally, depending on the type and location of the tumor. Overall, radiation therapy is prescribed according to the tumor's stage, grade, location, and other factors. Radiation therapy has several side effects, such as fatigue, skin irritation, and changes in the bowel or bladder function. The treatment can cause temporary or permanent hair loss, nausea, and vomiting. Patients typically receive radiation therapy over several weeks, and the treatment is carefully monitored to minimize side effects.
Gene therapy and its Characteristics is an emerging medical approach that involves the introduction of genetic material into a patient's cells to correct or treat genetic diseases. It involves modifying or replacing defective or missing genes that cause diseases, such as cancer. Researchers use several techniques to deliver genetic material, such as via a virus, a non-viral chemical compound, or physical methods such as electroporation. Gene therapy can be divided into two categories; somatic cell therapy and germ line therapy. Somatic cell therapy targets non-reproductive cells, with the aim of correcting or modifying cells that are causing diseases.
Germ line therapy targets gametes, which are the cells that carry genetic material from one generation to the next. Germ line therapy is still controversial due to ethical concerns around the potential for inherited genetic changes. One of the key challenges for gene therapy is finding safe and effective ways to deliver genetic material to cells without harming them. Other challenges include ensuring that only targeted cells receive the genetic modification, preventing immune system rejection, and monitoring long-term outcomes.
Radiation therapy and Gene therapy Combination Combining radiation therapy with gene therapy has emerged as an innovative treatment approach in cancer treatment with promising results. Researchers are exploring the potential of using gene therapy to sensitize cancer cells to radiation therapy. Gene therapy can target specific cellular mechanisms that underlie tumor cell resistance to radiation therapy. By modifying the cancer cells before radiation therapy, the cancer cells become more vulnerable to the radiation therapy. Combining radiation therapy with gene therapy also has the potential to improve the efficacy of standard cancer treatments. When combined with targeted therapy, radiation therapy can make a more potent and long-lasting contribution to reducing tumor growth. Delivery of gene therapy and radiation therapy at different time points can help to maximize the benefits offered by both therapies. For example, gene therapy can be delivered before radiation therapy to sensitize tumor cells, increasing the likelihood of success for radiation therapy. Alternatively, gene therapy can follow radiation therapy to help eliminate remaining cancer cells that radiation therapy may have missed.
Radiation therapy and gene therapy are two distinct medical approaches used to treat several cancers. Combining both approaches has shown promise in improving cancer patients' prognosis and may pave the way for more effective cancer therapy treatments. The combination of gene therapy and radiation therapy may help overcome some of the limitations associated with individual therapies, leading to a more comprehensive approach to cancer therapy. However, further research is needed to better understand the optimal approach to combining gene therapy and radiation therapy and tailoring these therapies to individual patients.