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Erythema multiforme (EM) is mucocutaneous disease which has oral manifestations. It is clinically characterized by a “minor” form and a “major” form. It presents a diagnostic dilemma because the oral cavity has the ability to produce varied manifestations. Primary attacks of oral EM are confined to the oral mucosa but the subsequent attacks can produce more severe forms of EM involving the skin. Hence, it is important to identify and distinguish them from other ulcerative disorders involving oral cavity for early management. This article reports an unusual case of Erythema multiforme with oral and lip lesions along with typical target eye lesion at extremities. We emphasize on its early diagnosis and timely management.