Brenner Tumor of the Ovary - Therapeutic Management
Objective: Most Brenner ovarian neoplasms are benign, with only 1% being malignant. Ovarian cancer composed solely of malignant Brenner tumor (MBT) is extremely rare. Only a few cases have been reported in the literature. We describe a case of MBT of the ovary with review of literature. Methods: A 62-year-old woman followed for MBT with high cytonuclear grade (3 and 4) of the right ovary, with extension to the uterus and bladder. Total hysterectomy with bilateral salpingo-oophorectomy with pelvic lymphadenectomy was performed. Disease was classified pT3cN1R1, FIGO (Federation of Gynecology and Obstetrics) stage IIIC. To the extent of the disease the first-line of the chemotherapy was validated with the subsequent surgery eventual. Results: The patient received 7 courses of chemotherapy with carboplatin– paclitaxel. But the cyto-reduction was insufficient for surgery. Surveillance to 2 months objectified progression of the disease in abdominal lymph node. The patient received consecutively 5 lines of systemic therapy. The patient had an altered general condition and died at 33 months of diagnosis. Conclusion: MBTs ovary are extremely rare and there is no consensus on the therapeutic management of metastatic forms. Taking charge of systemic unfortunately rare cases reported has not been detailed. It seems necessary to identify all cases diagnosed in a database, and in order to harmonize the treatment of this rare disease.
NK Santoni, P Tomasini and MB Palmaro