Research Article Open Access

Current Approach of NMR-Based Metabolomics Practices as Diagnostic Potential

Abstract

Nuclear Magnetic Resonance (NMR) spectroscopy is a quantitative analytical tool commonly utilized for metabolomics analysis. The benefits afforded by advancing NMR techniques include robust, reproducible results that can provide rapid and accurate information about a variety of diseases. New technologies allow for quick, straightforward, and cost-effective screening for a range of disease markers. Some of the fields in which NMR may be useful include diagnosis of liver disease, kidney disease, neurological disorders, cardiovascular disease, and cancer. In particular, NMR is being more broadly used in metabolomics whereby metabolites are analyzed to more effectively diagnose and treat disease. Quantitative NMR (q-NMR) is a field of NMR spectroscopy dedicated to the measurement of analytes through signal intensity and its linear relationship with analyte concentration. Metabolomics based NMR exploits this quantitative relationship to identify and measure biomarkers within complex biological samples such as serum, plasma, and urine. In this review of quantitative NMR-based metabolomics, the advancements and limitations of current techniques for metabolite quantification will be evaluated as well as the applications of q-NMR in biomedical.

Komal Patel, Krutika Poshiya*, Vaibhav Patel

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