Dual Wavelength Spectrophotometric Method for Estimation of Cilnidipine and Telmisartan in Their Combined Dosage Form.
The study aim to develop simple, sensitive, rapid, accurate and precise spectrophotometric method for estimation on Cilnidipine (CIL) and Telmisartan (TEL) in combined dosage forms. Pure drug sample of Cilnidipine and Telmisartanwere dissolved in a methanol. From the overlain spectra, four wavelengths 264 nm (λ1), 297.4 nm (λ2), 229 nm (λ3)and 246.8 nm (λ4) were selected for quantitation of both the drugs by proposed Dual wavelength spectrophotometric method. The quantitative determination of CIL was carried out by measuring the absorbance difference at λmax of 264 nm and 297.4 nm where TEL shows same absorbance value. The quantitative determination of TEL was carried out by measuring the absorbance difference at 229 nm and 246.8 nm where CIL showed same absorbance value at both the wavelengths. The results of analysis were validated statistically and by recovery studies and found to be free from interferences. These methods obey Beer’s law in the concentration range 2-6 μg/ml and 3-15 μg/ml for CILand TELrespectively.
Shahin Vahora, Falgun Mehta, Usmangani Chhalotiya, and Dimal Shah