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Research Article Open Access

Performance Evaluation of Direct Compressible Excipient-Problend (Silicified Microcrystalline Cellulose USP-NF)


The present study carried out to performance evaluation of problend (Silicified Microcrystalline Cellulose USP-NF) for its functionality as diluent. Immediate release tablets of antihypertensive molecule, Atenolol were formulated and studied. Sodium starch glycolate (SSG) was used as disintegrate, Magnesium stearate and talc used as lubricant and glidant respectively. Silicified microcrystalline cellulose (problend) and sodium starch glycolate (super disintegrating agent) were used in different ratios for 3- level full factorial design by design expert (Ver. 12). Quality by Design (qbd) approach was applied to determine material and critical quality attributes. Effect of quantity of problend and SSG was evaluated on chosen responses. Pre-compression blends and tablets were evaluated for various quality parameters.

Saroj Jain, Seema Rohilla, Vijay Sharma, Rahul Patole

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