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Spectrophotometric Method for Estimation of Tenofovir Disoproxil Fumarate in Tablets

Abstract

A new, simple and cost effective UV-spectrophotometric method has been developed for estimation of tenofovir disoproxil fumarate in bulk and tablets. Tenofovir disoproxil fumarate was estimated at 260 nm in water after dissolving in methanol. The linearity was found to be in the range of 10 - 50 μg/ml. (Y=0.024X-0.037; r =1.00004 ). The results of analysis were validated statistically and by recovery studies and they demonstrated that the procedure is accurate, precise and reproducible (relative standard deviation <2%), while being simple, cheap and less time consuming. The proposed methods were successfully applied for the determination of tenofovir disoproxil fumarate in pharmaceutical formulations.

T Shela Rani, K Sujatha, K Chitra, Don Mathew Jacob, Ramya Yandapalli, D Manasa, and B Sushma

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