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Research Article Open Access

Ultraviolet Spectrophotometric Determination of Trifluoperazine. HCl in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity Testing.


A simple, accurate, precise, rapid, economical and sensitive UV spectrophotometric method has been developed for the determination of trifluoperazine Hydrochloride in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at 257 nm in distilled water. Beer's law was obeyed in the range of 10 -100 μg/ ml ,with molar absorptive of 5.284×103 , relative standard deviation of the method was less than 1.6%, and accuracy (average recovery %) was 100 ± 1.2 . No interference was observed from common excipients and additives often accompany with trifluoperazine Hydrochloride in pharmaceutical preparations .The method was successfully applied to the determination of trifluoperazine Hydrochloride in some pharmaceutical formulations (tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of trifluoperazine Hydrochloride in true samples.

Nief Rahman Ahmed

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