In vitro hepatocellular carcinoma evaluation of different extracts of medicinal plants

Joint Event on Asia Pacific Conference on Diabetes & Oncology

December 04-05, 2019 | Tokyo, Japan

Majed Bawazeer, Bathini Thissera, Mallique Qader,Ayman Banah, Mostafa E. Rateb, Mohammed Yaseen

University of the West of Scotland, United Kingdom

Posters & Accepted Abstracts: RRJMHS

Abstract

Cancer is a leading cause of death worldwide. According to WHO reports, more than 8.8 million deaths were recorded in 2015. Resistance on chemotherapeutic drugs has threaten the achievements of modern medicine. The extracts of the plant sources are rich in phytochemicals and they are proven to have promising bioactivities. Therefore, searching for new natural inhibitors is felt to be paramount to find broader range and novel products for the treatment of cancers with minimal side effects. In the current study, Ziziphus spina-christi (leaves), Ziziphus spina-christi (leaves), Asafoetida (resin), Ajwa Medina (seeds), Liquorice Root Powder (roots) chamomile flower (leaves), Bulk Herbs Thyme (leaves) and marigold flowers calendula (leaves) were collected from Saudi Arabia and United Kingdom in 2017. The dried plant samples were macerated and extracted using methanol. The resulting crude extracts were tested for their anti-proliferative activity against Hep G2 (hepatocellular carcinoma) cancer cell line using MTT assay. THe total crude extracts of all the tested samples showed more than 70% cytotoxic activity while, Asafoetida crude showed 98%, cytotoxic activity at 50 g/mL concentration. To identify the phytochemicals present in the active extracts of these plants, chemical profiling using GCMS and LC-HRESIMS are underway.

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