Process of Manufacturing Oral Drugs (Capsule)
Department of Biotechnology, Amity University, Noida, New-Delhi India
- *Corresponding Author:
- Poonam Jaggi
Department of Biotechnology
Amity University, Noida, New-Delhi India
Received date: 09/05/2016; Accepted date: 26/08/2016; Published date: 01/09/2016
Visit for more related articles at Research & Reviews: Journal of Pharmaceutics and Nanotechnology
Capsules are solid dosage forms in which substances are enclosed in either a soft or hard, soluble container or shells of suitable forms of gelatins. Capsules have the advantage of being tasteless, easily administered and easily in large quantities commercially. Capsule can be categorized into three – based on their mode of fabrication, based on their use and based on their physical form. For the production of the capsule starts with the dispense of the raw material. The raw material then undergoes the process of granulation where sieving is done and various binders are added. This is followed by drying, sizing and blending of the material. This material now goes for capsule filling after that goes for capsule polishing. After that all the capsules goes for primary packaging then secondary packaging.
Capsules; Dosage; Drugs; Gelatin
In pharmaceutical drugs or medicines, is chemical substances are used to treat, prevent, diagnoses a diseases or promote well-being [1-4]. Mostly drugs were obtained through the extraction from medicinal plants and but Pharmaceutical drugs may be used for a limited duration, or on a regular basis for the chronic disorders [5-7]. The routes of administration of drugs by:-
Capsules: In the manufacturing of pharmaceuticals capsules are solid dosage forms in which substances are enclosed in either a hard or soft, soluble containers or shell of a suitable form of gelatin [8-12]. Capsules have the advantage of being tasteless, easily administered or in large quantities commercially [13-18].
The two main types of capsules are:
Hard shelled capsules, which are the typically made using gelatins and contains dry, powdered ingredients or pellets made by e.g. processes of extrusion [19-21]. These are made in the two halves: a lower-diameter "body" that is filled and sealed with a higher diameter "cap" [22-25].
Soft shelled capsules, primarily used for oils and for active ingredients that are dissolved or suspended in oil [26,27].
Advantages of Capsules
It is smooth, slippery and easy to swallow.
It is Suitable for substances having bitter taste and unpleasant odour.
Minimum excipients required.
It is stable than liquid dosage forms.
It is easy to store and transport [28-30].
Disadvantages of Capsules
It is not suitable for the highly efflorescent materials.
Special conditions are required for storage.
It is not suitable for very soluble ingredients such as KCl, CaCl2, KBR, and NH4Br. When the capsules are broken contact with the wall of the stomach, then the solution will be concentrated so that irritate the stomach and the stomach becomes tense [31-34].
The methods involved in the manufacturing process are carried out in different rooms. There are different rooms all ocated for each procedure and careful testing or checks occur after a period of steps [35-39].
When the raw materials come they are kept in a room known as “Raw Material Room”. From there taken to the Lab for testing [40-44]. The different common tests that take place for the raw materials are:
HPLC test, etc.
Then the tested raw materials are taken to another room. From there on the manufacturing process of the capsules start [45-48].
Raw Material Testing of Capsules
Amoxycillin Trihydrate is (6R)-6-(α-4-hydroxyphenyl-D-glycylamino acid Trihydrate.
Amoxycillin Trihydrate contains not less than 95.0 per cent and not more than 100.5 per cent of C16H19N3O5S. It is c alculated on the anhydrous basis. Its molecular weight is 419.4 [49-52].
Category: - Antibacterial.
Dose: - The Equivalent of 750mg to 4.5 g of Amoxycillin daily in divided doses.
Description: - A white or crystalline powder.
Tests B may be omitted if tests A are carried out.
A. Determine by infrared absorption spectrophotometer. Compare the spectrum with that obtained with Amoxycillin Trihydrate RS or with the reference spectrum of Amoxycillin Trihydrate [53-58].
B. Place about 2 mg in a test tube. Moisten with 0.05 ml of water and add 2 ml of sulphuric acid formaldehyde rea gent. Mix the contents of the tubes by swirling; the solution is practically colourless. Place the tube in a water-bath f or 1 minute; a dark yellow colour develops [59-64].
Appearance of solution: - Dissolve 1.0 g in 11 ml of 0.5 M hydrochloric acid, and a further 1.0 g in a mixture of 3 ml of dilute ammonia solution and 7 ml of water [65-67].
pH:- 3.5 to 5.5, determined in a 0.2 per cent w/v solution .
Specific optical rotation: - +2900 to 3150, determined in a 0.2 per cent w/v solution in carbon dioxide free water.
N, N-Dimethylaniline: - It is not more than 20 ppm, determined by method A.
Water: - 11.5 to 14.5 per cent, determined on 0.1 g.
Assay:- Determine by High Performance liquid chromatography
Solvent mixture: - Dissolve 6.8 g of monobasic potassium phosphate in 1000 ml of the water and adjust the pH to 4 .5 with a 4.5 per cent w/v solution of potassium hydroxide [68-70].
Test solution: - Transfer a weighed quantity of about 120 mg of the substance under examination to a 100 ml volu metric flask. Dissolve in the solvent mixture by shaking and mixing if necessary with the aid of ultrasound and dilute to 100.0 ml with the solvent mixture. Use this solution within 6 hours [71-75].
Reference solution: - weigh a suitable quantity of Amoxycillin Trihydrate RS, Dissolve in the solvent mixture by shaki ng and mixing if necessary with the aid of ultrasound and dilute to obtain a solution having a known concentration o f about 1.2 mg per ml. Use this solution within 6 hours [76-80].
In mobile phase a mixture of 4 volumes of acetonitrile and 96 volumes of the solvent mixture .
Flow rate is 1.5 ml per minute.
Spectrophotometer set at 230 nm
Injection volume is 10 μl.
Inject the reference solution: - The test is not valid unless the capacity factor is between 1.2 and 2.8, the column eff iciency is not less than 1800 theoretical plates, the tailing factor is not more than 2.6 and the relative standard dev iations for replicated injections is not more than 2.0 per cent [82-85].
Inject the reference solution and test solution.
Calculate the content of C16H19N3O5S.
Store at a temperature not exceeding 30°.
Weighing: According to the calculated amount the tested raw materials are weighed and put in the mixer [86,87].
Mixing in cone blender: This process takes place in the instrument called cone blender mixer. Along with the active i ngredients or raw materials, excipient and preservatives were also added to the mixture [88-90].
Empty capsule loader: All the empty capsules put it into the machine and then all the capsules loaded it into the se quence [91,92].
Capsules filling: After loading it is taken into the capsule filling machine after that it is taken to the capsules into ca psules polishing machine [93,94].
Primary Packaging: There are two types of primary packing. They are:-
Alu Alu packing: In this, on both the sides there’s aluminum foil. It’s just that on one side, it’s printed.
Strip packing: In terms of packing material it’s similar to Alu Alu packing but the process of packing is different than it [95-97].
Secondary Packaging: In this step, the packed capsules in the strips are finally packed in the boxes.
The study aim of my project is to study the process of manufacturing of oral drugs. The study deals with the processes of how the oral drugs that we consume in our daily life are manufactured. The result was concluded that the manufacturing process of capsules and syrups were easy as compared to tablets. The first set of result tells us whether the raw material is pure or not. If the purity percentage is between 95.0- 100.5% the raw material is pure and it can be forwarded for the manufacturing of the capsules. The steps adopted for the manufacture of capsules are raw material testing, weighing, and mixing in cone blender, capsules filling, capsules polishing, packaging and dispatch. Amoxycillin Capsule obtained was a white or almost white crystalline powder. The Disintegration time for hard capsules is 25 minutes and 05 seconds but the acceptance criteria should be 30 minutes and for soft capsules it is 50 minutes and 05 seconds but the acceptance criteria should be 60 minutes [98-100].
- Koly SF, et al. An In Vitro Study of Binding of Aceclofenac and Pantoprazole with Bovine Serum Albumin by UV Spectroscopic Method. J Pharm Sci Emerg Drugs 2016;4:1.
- Kogawa AC, et al. Characterization of Darunavir: Β-Cyclodextrin complex and Comparison with the Forms of Darunavir Ethanolate and Hydrate. J Pharm Sci Emerg Drugs .2016;4:1
- Chaube R, et al. Pentachlorophenol-Induced Oocyte Maturation in Catfish Heteropneustes Fossils: An In Vitro Study Correlating with Changes in Steroid Profiles. J Pharm Sci Emerg Drugs. 2016;4:1.
- Pardhi D, et al. Evaluation of the Potential of Natural Biodegradable Polymers (Echinochloa Colonum Starch) and its Derivatives in Aqueous Coating of Hydrophilic Drugs. J Pharm Sci Emerg Drugs. 2016;4:1.
- Patel MN, et al. Synthesis, Characterization and Biological Elucidation of Mixed Ligand Cu(II) Complexes as Artificial Metallonucleases. J Pharm Sci Emerg Drugs.2015;3:1.
- Tsompos C, et al. The Effect of the Antioxidant Drug “U-74389G” on Uterus Inflammation during Ischemia Reperfusion Injury in Rats. J Pharm Sci Emerg Drugs. 2015;3:1.
- Swapnil S, et al. Healing Potential of Citrullus Lanatus in Acetic Acid Induced Ulcerated Rats. J Pharm Sci Emerg Drugs. 2015;3:1.
- Rana VS. Separation and Identification of Swertiamarin from Enicostema axillare Lam. Raynal by Centrifugal Partition Chromatography and Nuclear Magnetic Resonance-Mass Spectrometry. J Pharm Sci Emerg Drugs.2014; 2:1.
- Resende GOD, et al. First Dose Combination Studies of Anti-Tuberculosis Drugs With Piperic Acid. J Pharm Sci Emerg Drugs. 2014;2:1.
- Chiririwa H. Synthesis, Characterization of Gold (III) Complexes and an in vitro Evaluation of their Cytotoxic Properties. J Pharm Sci Emerg Drugs. 2014;2:1.
- Naik DR, et al. Release Kinetics of Cellulosic Nano particulate Formulation for Oral Administration of an Antiviral Drug: Effect of Process and Formulation variables. J Pharm Sci Emerg Drugs. 2014; 2:1.
- Russu WA .The Climate is Right to Accelerate New Drug Development for Neglected Diseases. Outlook Emerg Drugs. 2012;1:1.
- Chang CW and Ning B.The Needs and Challenges in Assessing Genetic Variants for Drug Efficacy and Safety. J Biomark Drug Dev. 2012;1:1.
- Zhu and Fan GC. Whether Circulating miRNAs or miRNA-Carriers Serve as Biomarkers for Acute Myocardial Infarction. J Biomark Drug Dev. 2012;1:1.
- Akintunde JK, et al. Sub-Chronic Treatment of Sildernafil Citrate (Viagra) on some Enzymatic and Non-enzymatic Antioxidants in Testes and Brain of Male Rats. J Pharm Drug Deliv Res. 2012;1.2.
- Al-Malah KI. Prediction of Aqueous Solubility of Organic Solvents as a Function of Selected Molecular Properties. J Pharm Drug Deliv Res. 2012;1:2.
- Sharma B, et al. Formulation, Optimization and Evaluation of Atorvastatin Calcium Loaded Microemulsion. J Pharm Drug Deliv Res. 2012;1:3.
- Zhou Y, et al. Therapeutic Effects of Sinomenine Microemulsion-Based Hydrogel on Adjuvant-Induced Arthritis in Rats. J Pharm Drug Deliv Res. 2012;1:3.
- Ibtehal S, et al. Preparation of Zaleplon Microparticles Using Emulsion Solvent Diffusion Technique. J Pharm Drug Deliv Res. 2012;1:3.
- Y. Bruce Yu .Prospect of 19F MRI-Guided Drug Delivery. J Pharm Drug Deliv Res. 2012;1:1.
- Kipping T and Rein H. Development of Extruded Starch Based Formulations Aimed for Local Drug Delivery to Oral Cavity. J Pharm Drug Deliv Res. 2012;1:1.
- Meier-Davis SR, et al. Enhancing the Skin Flux of Tolnaftate Utilizing the Novel Excipient, Dodecyl-2-N,N-Dimethylaminopropionate (DDAIP). J Pharm Drug Deliv Res. 2012;1:1.
- Vijayarajkumar P, et al. Efavirenz Loaded Novel Citric Acid Dendritic Architecture for Increased Solubility and Sustained Delivery. J Pharm Drug Deliv Res. 2012;1:1.
- Saxena Brij B, et al. Development of a Nanoporous Elastomere Intra-Vaginal Ring (IVR) for the Sustained Release of Non-Hormonal Contraceptives. J Pharm Drug Deliv Res. 2012;1:1.
- Isabel S and Paula G .Encapsulation of Fluoroquinolones in 1-Palmitoyl-2-Myristoyl-Phosphatidylcholine: Cholesterol Liposomes. J Pharm Drug Deliv Res. 2013;2:1.
- Satya Krishna HP, at al. Solubility and Dissolution Enhancement of Candesartan Cilexetil by Liquisolid Compacts. J Pharm Drug Deliv Res. 2013;2:2.
- Scott D and Bae Y .Block Copolymer Crosslinked Nanoassemblies Co-entrapping Hydrophobic Drugs and Lipophilic Polymer Additives. J Pharm Drug Deliv Res. 2013;2:2.
- Mohamed Idrees RY and Khalid A .Comparative Modeling of Serotonin Receptors 5ht2a and 5ht2c and In-silico Investigation of their Potential as Off-Target to Ethinylestradiol. J Pharm Drug Deliv Res. 2013;2:2.
- ElShaer A, et al. Preparation and Evaluation of Amino Acid Based Salt Forms of Model Zwitterionic Drug Ciprofloxacin. J Pharm Drug Deliv Res. 2013;2:1.
- Frank T. Population Pharmacokinetics of Lixisenatide, a Once-Daily Human Glucagon-Like Peptide-1 Receptor Agonist, in Healthy Subjects and in Patients with Type 2 Diabetes. J Pharm Drug Deliv Res. 2013;2:1.
- Akash MSH, et al. Characterization of Ethylcellulose and Hydroxypropyl Methylcellulose Microspheres for Controlled Release of Flurbiprofen. J Pharm Drug Deliv Res. 2013;2:1.
- Dey B, et al. Comparative Evaluation of Hypoglycemic Potentials of Eucalyptus Spp. Leaf Extracts and their Encapsulations for Controlled Delivery. J Pharm Drug Deliv Res. 2012;3:2.
- Efentakis M and Siamidi A .Design and Evaluation of a Multi Layer Tablet System Based on Dextran. J Pharm Drug Deliv Res. 2014;3:2.
- Humayoon R, et al. Quality Control Testing and Equivalence of Doxycycline Hyclate (100 mg) Capsule Brands under Biowaiver Conditions. J Pharm Drug Deliv Res. 2014;3:2.
- Ranjna CD, et al. Inhibiting Human Lactate Dehydrogenase-C for Male Fertility Control; Initial Hits. J Pharm Drug Deliv Res. 2014;3:2.
- Brijesh KV, et al. Physicochemical Characterization and In-Vitro Dissolution Enhancement of Bicalutamide-Hp-Β-Cd Complex. J Pharm Drug Deliv Res. 2015;3:2.
- Gunjan J and Swarnlata S .Topical Delivery of Curcuma Longa Extract Loaded Nanosized Ethosomes to Combat Facial Wrinkles. J Pharm Drug Deliv Res. 2014;3:1.
- Ogaji IJ, et al. Some Characteristics of Theophylline Tablets Coated with Samples of Grewia Gum obtained from a Novel Extraction. J Pharm Drug Deliv Res. 2014;3:1.
- Chopra AK, et al. Box-Behnken Designed Fluconazole Loaded Chitosan Nanoparticles for Ocular Delivery. J Pharm Drug Deliv Res. 2014;3:1.
- Mahipalreddy D, et al. Preparation and Evaluation of Ketoprofen Enteric Coated Mini Tablets for Prevention of Chronic Inflammatory Disease. J Pharm Drug Deliv Res. 2015;4:2.
- Wiley TS, et al. H1R Antagonists for Brain Inflammation and Anxiety: Targeted Treatment for Autism Spectrum Disorders. J Pharm Drug Deliv Res. 2015;4:3.
- Nair AK, et al. Development and Comparative Assessment of Hydrocolloid Based Against Wax Based Gastro Retentive Bilayered Floating Tablet Designs of Atorvastatin Calcium Using Qbd Approach. J Pharm Drug Deliv Res. 2015;4:3.
- Joshi RR and Devarajan PV. Anionic Self Micro-Emulsifying Drug Delivery System (SMEDDS) Of Docetaxel for Circulation Longevity. J Pharm Drug Deliv Res. 2015;4:3.
- Ferreira H, et al. Deformable Liposomes for the Transdermal Delivery of Piroxicam. J Pharm Drug Deliv Res. 2015; 4:4.
- Solomon AO, et al. Making Drugs Safer: Improving Drug Delivery and Reducing Side-Effect of Drugs on the Human Biochemical System. J Pharm Drug Deliv Res. 2015;4:4.
- Orji JI, et al. Physicochemical Properties of Co-Precipitate of Plantain Peel Cellulose and Gelatin. J Pharm Drug Deliv Res. 2015;4:4.
- Panchangam RBS and Dutta T .Engineered Nanoparticles for the Delivery of Anticancer Therapeutics. J Pharm Drug Deliv Res. 2015;4:1.
- Kaliappan I, et al. Structural Elucidation of Possible Metabolic Profile of Mangiferin by Oral and Intraperitoneal Administration. J Pharm Drug Deliv Res. 2015;4:1.
- Coyne CP and Narayanan L. Fludarabine-(C2-methylhydroxyphosphoramide)-[anti-IGF-1R]: Synthesis and Selectively “Targeted” Anti-Neoplastic Cytotoxicity against Pulmonary Adenocarcinoma (A549). J Pharm Drug Deliv Res. 2015 ;4:1.
- Koteswari P, et al. Fabrication of a Novel Device Containing Famotidine for Gastro Retentive Delivery Using Carbohydrate Polymers. J Pharm Drug Deliv Res. 2015;4:1.
- Bassani AS, et al. In Vitro Characterization of the Percutaneous Absorption of Lorazepam into Human Cadaver Torso Skin, Using the Franz Skin Finite Dose Model. J Pharm Drug Deliv Res. 2015;4:2.
- Lokesh BVS and Kumar PV. Enhanced Cytotoxic Effect of Chemically Conjugated Polymeric Sirolimus against HT-29 Colon Cancer and A-549 Lung Cancer Cell Lines. J Pharm Drug Deliv Res.2015;4:2.
- Satyavathi K, et al. Formulation and In-Vitro Evaluation of Liposomal Drug Delivery System of Cabazitaxel. J Pharm Drug Deliv Res. 2015;4:2.
- Radu CD, et al. Comparative Study of a Drug Release from a Textile to Skin. J Pharm Drug Deliv Res. 2015;4:2.
- Strehlow B, et al. A Novel Microparticulate Formulation with Allicin In Situ Synthesis. J Pharm Drug Deliv Res. 2016; 5:1.
- Abdou EM and Ahmed NM. Terconazole Proniosomal Gels: Effect of Different Formulation Factors, Physicochemical and Microbiological Evaluation. J Pharm Drug Deliv Res. 2016;5:1.
- Usta A and Asmatulu R .Synthesis and Analysis of Electrically Sensitive Hydrogels Incorporated with Cancer Drugs. J Pharm Drug Deliv Res. 2016;5:2.
- Král V, et al. Multifunctional Bile Acid Derivatives as Efficient RNA Transporters (Carriers). J Pharm Drug Deliv Res. 2016;5:2.
- Olaso I, et al. A Comparative Study of the Treatment of Giardiasis with Commercially Marketed Medicine, Metronidazol with Compounding Medicine at a Rural Hospital in Ethiopia. J Pharm Drug Deliv Res. 2016;5:2.
- Mishra S and Gomase VS .Prediction of Antigenic MHC Peptide Binders and TAP Binder of COX1 Protein through in silico Approach. J Drug Metab Toxicol. 2016;7:201.
- Copelli D, et al. Actuator Performance Comparison by an Integrated Multivariate Approach. Pharm Anal Acta. 2016;7:483.
- Madhavi K, et al. Preparation, Optimization and Characterization of Eudragit Coated Chitosan Piroxicam Microspheres Intended for the Treatment of Rheumatoid Arthritis. Pharm Anal Acta. 2016;7:485.
- Raveendra BG, et al. UV Spectrophotometric Method for the Estimation of Roflumilast in Human Serum. Pharm Anal Acta. 2016;7:487.
- Tabassum A, et al. Synthetic Characterization of Complexes of Rosuvastatin and Some ACE Inhibitors: Pharmacological Evaluation. Pharm Anal Acta. 2016;7:488.
- Singh D and Shailajan S .Simultaneous Quantification of Pharmacologically Active Markers Quercetin, Kaempferol, Bergenin and Gallic Acid from Cuscuta Campestris Yuncker Using HPTLC. Pharm Anal Acta. 2016;7:490.
- Maria A, et al. An Emergence of a MRAB: With Growing Necessity of Antibiotic Pharmacist in Infectious Era. Pharm Anal Acta. 2016;7:491.
- Seema A, et al. Development and Validation of HPLC Method for Estimation of Pregabalin in Bulk & Capsule Dosage Form. Pharm Anal Acta. 2016;7:492.
- Saini MK and Murthy SSN .Acetaminophen, Methocarbamol, Guaifenesin and Mephenesin in Propylene Glycol: Solubility and Phase Behaviour for Use in Medical Industry. Pharm Anal Acta. 2016;7:493.
- Yunes JS, et al. Identification of the Toxic Pentapeptide Nodularin in a Cyanobacterial Bloom in a Shrimp Farm in South American Atlantic Coast. Pharm Anal Acta. 2016;7:479.
- Mahendra Kumar T, et al. Evaluation of the Isotopic Abundance Ratio in Biofield Energy Treated Resorcinol Using Gas Chromatography-Mass Spectrometry Technique. Pharm Anal Acta. 2016;7: 481.
- Eldin AB, et al. Eco-Friendly HPTLC Method for Simultaneous Analysis of Simvastatin and Ezetimibe in Pharmaceutical Preparations and Trying to Use Limonene as Eluent. Pharm Anal Acta. 2015;6:417.
- Gautam BPS, et al. Synthesis, Characterization, Single Crystal Structural Studies, Antibacterial Activity and DFT Investigations of 2-Chloro-5-Ethoxy-3,6-Bis(Methylamino)-1,4-Benzoquinone. Pharm Anal Acta. 2015;6:418.
- Akl MA, et al. Surfactant Assisted Separation-Spectrophotometric Procedure for the Trace Analysis of Copper (II) in Drug and Water Samples Using a Heterocyclic Pyridyl Azo Dye. Pharm Anal Acta. 2015;6:421.
- Prabavathi N, et al. Spectroscopic Investigation (FT-IR, FT-Raman, NMR and UV-Vis), Conformational Stability,NBO and Thermodynamic Analysis of 1-(2-Methoxyphenyl) Piperazine and 1-(2-Chlorophenyl) Piperazine by DFT Approach. Pharm Anal Acta. 2015;6:391.
- Coutinho EC, et al. Conformation of the Antigenic Peptide Tyrosinase (192-200) in Water and DMSO-d6 by NMR Spectroscopy and MD Simulations. Pharm Anal Acta. 2015;6:392.
- Gaudin K, et al. In Vitro Ceftriaxone Stability at New-borns’ Rectal PH Assessed By UV and HPLC Methods. Pharm Anal Acta. 2015;6:393.
- Amagai T, et al. Determination of Nicotine Exposure Using Passive Sampler and High Performance Liquid Chromatography. Pharm Anal Acta. 2015;6:399.
- Kojima S, et al. Broadband Terahertz Time-Domain and Low-Frequency Raman Spectroscopy of Crystalline and Glassy Pharmaceuticals. Pharm Anal Acta. 2015;6:401.
- Singh N, et al. An Efficient and Fast Process for the Removal of Trivalent and Hexavalent Chromium from Contaminated Water Using Zinc Peroxide Nanomaterial. Pharm Anal Acta. 2015;6:412.
- Klungel OH, et al. Instrumental Variable Analysis in Epidemiologic Studies: An Overview of the Estimation Methods. Pharm Anal Acta. 2015;6:353.
- Hadad GM, et al. Simultaneous Determination of Clarithromycin, Tinidazole and Omeprazole in Helicure Tablets Using Reflectance Near-Infrared Spectroscopy with the Aid of Chemometry. Pharm Anal Acta.2015;6:354.
- Menaa F. Tapping into Deep-Water Reservoirs to Overcome Antibiotic Resistance through Bacteria-Producing Unique Secondary Metabolites. Pharm Anal Acta. 2015;6:e172.
- Hee KH, et al. Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantification of Ertapenem in Human Serum. Pharm Anal Acta. 2015;6:358.
- Sriharsha J, et al. Method Development and Validation for Simultaneous Estimation of Dexlansoprazole and Meloxicam by Rp-Hplc. Pharm Anal Acta. 2015;6:370.
- Talaat W. Micellar Liquid Chromatographic Determination of Lamivudine, Indinavir and Ketoconazole in Dosage Forms and Biological Fluids. Pharm Anal Acta. 2015;6:327.
- Lu Y, et al .Development and Optimization of a RP-HPLC Method to Quantify Midazolam in Rat Plasma after Transdermal Administration: Validation and Application in Pharmacokinetic Study. Pharm Anal Acta. 2015;6:329.
- Patil PM, et al. A Validated Stability–Indicating HPLC Method estimation of ClonazepamIn the bulk drug and Pharmaceutical Dosage Form. Pharm Anal Acta. 2015;6:332.
- Belal F, et al. Micellar Liquid Chromatographic Determination of Idrocilamide in Dosage Form and Biological Fluids:Application to Stability Study. Pharm Anal Acta. 2015;6:335.
- Randviir EP and Banks CE. The Synergy of Electrochemical Impedance Spectroscopy and Medicinal Technology. Pharm Anal Acta. 2015;6:336.
- Takegami S, et al. Application of 19F NMR Spectroscopy Using a Novel a-Tocopherol Derivative as a 19F NMR Probe for a Pharmacokinetic Study of Lipid Nano-Emulsions in Mice. Pharm Anal Acta. 2015;6:339.
- Kelani KM, et al. Spectrophotometric and Chemometric Methods for Simultaneous Determination of Two Anti-Hypertensive Drugs in their Combined Dosage Form. Pharm Anal Acta.2014;6:321.
- Dasgupta TK, et al. Spectroscopic & Chromatographic Methods for Quantitative Analysis of Phospholipid Complexes of Flavonoids – A Comparative Study. Pharm Anal Acta. 2014;6:322.
- Rathee P, et al. Statistical Design for Optimization and Determination of Tizanidine Hcl using Folin-Ciocalteu (Fc) as Chromogenic Reagent. Pharm Anal Acta. 2014;5:307.
- Qumbar M, et al. DOEBased Stability Indicating RP-HPLC Method for Determination of Lacidipine in Niosomal Gel in Rat: Pharmacokinetic Determination. Pharm Anal Acta. 2014;5:314.
- Salvia MV, et al. Comparison of Two Analytical Methods for the Determination of Traces of Veterinary Antibiotics and Steroid Hormones in Soil Based on Pressurised Liquid Extraction (PLE) and Quick, Easy, Cheap, Effective, Rugged, Safe (Modified-Quechers) Extraction. Pharm Anal Acta. 2014;5:315.
- Cone EJ, et al. The New Science of Abuse-Deterrence Assessment of Pharmaceutical Products; FDA Proposed Guidance and Category 1 Laboratory Studies. Pharm Anal Acta. 2014;5:317.
- Saeed Arayne M, et al. Monitoring of Pregabalin in Pharmaceutical Formulations and Human Serum Using UV and RPHPLC Techniques: Application to Dissolution Test Method. Pharm Anal Acta. 2014;5:287.
- Sherley JL. Accelerating Progress in Regenerative Medicine by Advancing Distributed Stem Cell-based Normal Human Cell Biomanufacturing. Pharm Anal Acta. 2014;5:286.
- Lin YW, et al. Cinnamophilin Inhibits Neutrophilic Respiratory Burst and Protects Against Ischemia-Reperfusion Brain Damage. Pharmaceut Anal Acta. 2013;4:272.
- Sharma HK, et al. Development of Spectrophotometric Method for Quantitative Estimation of Amlodipine Besylate, Olmesartan Medoxomil and Hydrochlorthiazide in Tablet Dosage Form. Pharm Anal Acta. 2011;2:126.