Targeted Drug delivery systems
Department of Pharmaceutics, SRM University, Chennai, Tamil nadu, India
- *Corresponding Author:
- Gautami J
Department of Pharmaceutics, SRM University, Chennai, Tamil Nadu, India
Received date: 08 January 2015 Accepted date: 09 February 2015
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Drug delivery system is a device that empowers the Introduction of a therapeutic substance in the body and enhances the efficacy and safety by controlling the rate, time, and place of release of drug in the body. This methodology includes organization of the therapeutic product, the release of the active ingredients by the product, and the resulting transport of the active ingredients over the biological membrane [1 - 3].
Types of conventional drug delivery
Conventional drug delivery system includes the formulation of the drug into a suitable form [4 - 7]
• Solid dosage forms: Tablets, capsules, powders
• Liquid dosage forms: Mono phasic: Syrups, Elixirs
Biphasic: Suspensions, Emulsions
Convenience in Administration, Non invasive, accurate dose, Higher compliance, Economical [8 - 10].
Unconscious patients cannot take dose, Low solubility and permeability, Degradation by Gastro Intestinal flora, first pass metabolism, Food interactions, and Poor bioavailability.
High concentration of conventional drugs is required for desired therapeutic effect this leads to toxicity. Disadvantages with conventional Drugs can be overcome by using targeted drug delivery systems. Delivery of drug to specific part of body. [11 - 15]
Therapeutic benefits of targeted Drug Delivery systems:
Increased efficacy of drug, Site specific delivery, low toxic effects, treatment for previously incurable diseases, better patient compliance, Deliver the drug at the right point, in the right time and with right dosage. [16-27]
Types of targeted Drug delivery systems:
Liposome’s are spherical vesicles in which lipid layer enclosed in aqueous environment. Anthracyclines
Solid small spherical particles 1 μm to 1000 μm contains a microscopic hollow sphere
Particle size ranges from 10-9m .Microscopic particle size is measured in nano meters. small object that behaves as a whole unit with respect to its transport and properties.
smaller than 100 nanometres.Composed of atoms in either a single- or poly-crystalline arrangement.
Wire with a diameter of only a few nanometres. structures that have a thickness or diameter constrained to tens of nanometers or less and an unconstrained length
Tubular molecule consists of a large number of carbon atoms.
clear, thermodynamically stable, isotropic liquid mixtures of oil, water and surfactant,Aqueous phase contain salt /other ingredients oil phase contain complex mixture of different hydrocarbons and olefins.
Phospho lipid elastic nanovesicles. contains ethanol 20–45%. Deliver the drug to outer layer of skin.
Exhibit high current densities due to the presence of 100 crystallographic planes
Self drug containing dosage form which when applied to skin deliver the drug to skin at controlled rate for longer period of time.
When gel and emulsion are used in combination with nano sized it is known as emulgel
Dimensions range from 1–100 nm. Nano rods synthesized from metals or semiconducting materials.
Carbon nano tube:
Tubular cylinders of carbon atoms, contains mechanical, electrical, thermal, optical and chemical properties at the individual tube level [56-60].
Targeted drug delivery used to treat cardiovascular diseases, Cancer tumors and diabetes, used for treatment of tuberculosis, CNS, Oncology, Cardiovascular, pulmonary and infectious disease [28 - 55].
To overcome the limitations of conventional drug delivery system, continuous steady rate of drug at the site of action targeted Drug Delivery systems was developed it requires very small amount of drug comparatively to conventional dosage forms. Due to this, the toxicity inside the body and side effects of the drug on organs are reduced. Drugs can be delivered to the exact location with the right amount of dosage. Research studies are still going on targeted drug delivery system
- Khan DR .The use of Nanocarriers for Drug Delivery in Cancer Therapy. J Cancer Sci Ther. 2010; 2: 058-062.
- Saxena Brij B, Koldras Kristen E, Mukul S, Nancy N, Premila R, et al. Development of a Nanoporous Elastomere Intra-Vaginal Ring IVR for the Sustained Release of Non-Hormonal Contraceptives. J Pharm Drug Deliv Res. 2012; 1:1.
- D’Cruz OJ, Uckun FM .Targeting Spleen Tyrosine Kinase SYK for Treatment of Human Disease. J Pharm Drug Deliv Res. 2012; 1:2.
- Zhou Y, Gui S, Wang J, Qian S, Pan .Therapeutic Effects of Sinomenine Microemulsion-Based Hydrogel on Adjuvant-Induced Arthritis in Rats. J Pharm Drug Deliv Res. E 2012; 1:3.
- Yeoh E, Othman K, Ahmad H. Characterization of Ethylcellulose and Hydroxypropyl Methylcellulose Microspheres for Controlled Release of Flurbiprofen. J Pharm Drug Deliv Res. 2013; 2:2.
- Chopra AK, Marwaha RK, Kaushik D, Dureja H .Box-Behnken Designed Fluconazole Loaded Chitosan Nanoparticles for Ocular Delivery. J Pharm Drug Deliv Res. 2014 ; 3:1
- Gunjan J, Swarnlata S .Topical Delivery of Curcuma Longa Extract Loaded Nanosized Ethosomes to Combat Facial Wrinkles. J Pharm Drug Deliv Res. 2014; 3:1.
- Amirthalingam T, Kalirajan J, Chockalingam A .Use of Silica- Gold Core Shell Structured Nanoparticles for Targeted Drug Delivery System. J Nanomedic Nanotechnol. 2011 ; 2:119.
- Kondrashina OV. A Targeted Drug Delivery System of Gd3+ for Neutron Capture Therapy against Cancer is Metalorganic Magnetic Nanoparticles. J Nanomedine Biotherapeutic Discov. 2013;3:116.
- Saboktakin MR, Tabatabaie RM, Maharramov A, Ramazanov MA .Synthesis and Characterization of Biodegradable Thiolated Chitosan Nanoparticles as Targeted Drug Delivery System. J Nanomedic Nanotechnol. 2011; S4:001.
- Le TTD, Dang TML, Hoang TMN, La TH, Nguyen TMH, et al. Novel Anti-HER2 ScFv Targeted-Docetaxel Nanoparticles in Therapy of HER2 Overexpressed Cancer. J Nanomed Nanotechnol . 2015; 6:267.
- El-Deeb NM, El-Sherbiny IM, El-Aassara MR, Hafez EE .Novel Trend in Colon Cancer Therapy Using Silver Nanoparticles Synthesized by Honey Bee. J Nanomed Nanotechnol. 2015; 6:265.
- Matilda A, Oskari E, Topias S, Matilda O .A Review on Ophthalmology using Nanotechnology. J Nanomed Nanotechnol. 2015 ; 6:272.
- Zhang X, Pang Z, Liu H, Zhai T. Achieving Continuous Sub-100- nm Plasmonic Nanowires as Long as Centimeters. J Nanomedic Nanotechnol. 2011; 6:273.
- Hafaiedh I, Abdelghani A .Impedance Spectroscopy of Supported Multiwalled Carbon Nanotubes for Immunosensor Applications. J Nanomedic Nanotechnol . 2012; 6:275.
- Abbas M, Torati SR, Lee CS, Rinaldi C, Kim CG .Fe3O4/SiO2 Core/ Shell Nanocubes: Novel Coating Approach with Tunable Silica Thickness and Enhancement in Stability and Biocompatibility. J Nanomed Nanotechnol. 2014; 5:244.
- Silva HR, Luz GM, Satake CY, Correa BC, Sarmento VHV, et al. Surfactant-based Transdermal System for Fluconazole Skin Delivery. J Nanomed Nanotechnol. 2014; 5:231.
- Pantidos N, Horsfall LE .Biological Synthesis of Metallic Nanoparticles by Bacteria, Fungi and Plants. J Nanomed Nanotechnol. 2014; 5:233.
- Weber M, Zoschke C, Sedighi A, Fleige E, Haag R, et al. Free Energy Simulations of Cargo-Carrier Interactions for Core-Multishell Nanotransporters. J Nanomed Nanotechnol. 2014; 5:234.
- Moore TL, Schreurs AS, Morrison RA, Jelen EK, Loo J, et al. Polymer-Coated Hydroxyapatite Nanoparticles for the Delivery of Statins. J Nanomed Nanotechnol. 2014; 5:237.
- Venturini M, Mazzitelli S, Micetic I, Benini C, Fabbri J, et al. Analysis of Operating Conditions Influencing the Morphology and In vitro Behaviour of Chitosan Coated Liposomes. J Nanomed Nanotechnol. 2014; 5:211.
- Vidanapathirana AK, Thompson LC, Odom J, Holland NA, Sumner SJ, et al. Vascular Tissue Contractility Changes Following Late Gestational Exposure to Multi-Walled Carbon Nanotubes or their Dispersing Vehicle in Sprague Dawley Rats. J Nanomed Nanotechnol. 2014; 5:201.
- Montagu A, Saulnier P, Cassissa V, Rossines E, Eveillard M, et al. Aromatic and Terpenic Compounds Loaded in Lipidic Nanocapsules: Activity against Multi-drug Resistant Acinetobacter baumannii Assessed in vitro and in a Murine Model of Sepsis. J Nanomed Nanotechnol. 2014; 5: 206
- Eid AM, El-Enshasy HA, Aziz R, Elmarzugi NA .Preparation, Characterization and Anti-Inflammatory Activity of Swietenia macrophylla Nanoemulgel. J Nanomed Nanotechnol. 2014; 5:190.
- Rocha- Filho PA, Camargo MFP, Ferrari M, Maruno M .Influence of Lavander Essential Oil Addition on Passion Fruit Oil Nanoemulsions: Stability and In vivo Study. J Nanomed Nanotechnol. 2014; 5:198.
- Rachmawati H, Haryadi BM .The Influence of Polymer Structure on the Physical Characteristic of Intraoral Film Containing BSA-loaded Nanoemulsion. J Nanomed Nanotechnol. 2014; 5:187.
- Shah H, Manikandan E, Basheer Ahmed M, Ganesan V .Enhanced Bioactivity of Ag/ZnO Nanorods-A Comparative Antibacterial Study Sbds. J Nanomed Nanotechol. 2013; 4:168.
- Mehrotra A, Nagarwal RC, Pandit JK .Fabrication of Lomustine Loaded Chitosan Nanoparticles by Spray Drying and in Vitro Cytostatic Activity on Human Lung Cancer Cell Line L132. J Nanomedic Nanotechnolo. 2010; 1:103.
- Dibirdik I, Yiv S, Qazi S, Uckun FM .In vivo Anti-Cancer Activity of a Liposomal Nanoparticle Construct of Multifunctional Tyrosine Kinase Inhibitor 4-4’-Hydroxyphenyl-Amino-6,7-Dimethoxyquinazoline. J Nanomedic Nanotechnolo. 2010; 1:101.
- Lukianova-Hleb EY, Oginsky AO, Shenefelt DL, Drezek RA, Hafner JH, et al. Rainbow Plasmonic Nanobubbles: Synergistic Activation of Gold Nanoparticle Clusters. J Nanomedic Nanotechnol. 2011; 2:104.
- Eshita Y, Higashihara J, Onishi M, Mizuno M, Yoshida J, et al. Mechanism of the Introduction of Exogenous Genes into Cultured Cells Using DEAE-Dextran-MMA Graft Copolymer as a Non-Viral Gene Carrier. II. Its Thixotropy Property. J Nanomedic Nanotechnol. 2011; 2:105.
- Nakamura J, Nakajima N, Matsumura K, Hyon SH. In Vivo Cancer Targeting of Water-Soluble Taxol by Folic Acid Immobilization. J Nanomedic Nanotechnol. 2011; 2:106.
- Mizuno K, Zhiyentayev T, Huang L, Khalil S, Nasim F, et al. Antimicrobial Photodynamic Therapy with Functionalized Fullerenes: Quantitative Structure-activity Relationships. J Nanomedic Nanotechnol. 2011; 2:109.
- Elgindy N, Elkhodairy K, Molokhia A, ElZoghby A. Biopolymeric Nanoparticles for Oral Protein Delivery: Design and In Vitro Evaluation. J Nanomedic Nanotechnol. 2011; 2:110.
- Patil A, Chirmade UN, Slipper I, Lamprou DA, Urquhart A, Douroumis D .Encapsulation of Water Insoluble Drugs in Mesoporous Silica Nanoparticles using Supercritical Carbon Dioxide. J Nanomedic Nanotechnol. 2011; 2:111.
- Thomas S, Waterman P, Chen S, Marinelli B, Seaman M, et al. Development of Secreted Protein and Acidic and Rich in Cysteine SPARC Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer. J Nanomedic Nanotechnol. 2011; 2:112.
- Ostafin AE, Batenjany MM. Nanomedicine Making Headway across the Blood Brain Barrier. J Nanomed Nanotechol. 2012; 3:e123.
- Chen Y, Chen G, Zhao Y, Wang W. Indocyanine Green-Loaded Nanocarriers as Contrast Agents for NIR Fluorescent Optical Imaging. J Nanomed Nanotechol. 2012; 3:e122.
- Ivanova IA, Tasheva-Terzieva E, Angelov O, Krusteva L, Andonova I, et al. Effect of ZnO Thin Films on Survival of Pseudomonas Cells. J Nanomed Nanotechol. 2012; 3:148.
- Martirosyan KS .Thermosensitive Magnetic Nanoparticles for Self-Controlled Hyperthermia Cancer Treatment. J Nanomed Nanotechol. 2012; 3:e112.
- Kummer KM, Taylor EN, Webster TJ .Anodized Nanotubular TiO2 Structures Significantly Improve Titanium Implant Materials In Vitro and In Vivo. J Nanomedic Nanotechnol. 2012; 3:e107.
- Rahiman S, Tantry BA .Nanomedicine Current Trends in Diabetes Management. J Nanomed Nanotechol. 2012; 3:137.
- Mashhadizadeh MH, Amoli-Diva M. Drug-Carrying Amino Silane Coated Magnetic Nanoparticles as Potential Vehicles for Delivery of Antibiotics. J Nanomed Nanotechol. 2012; 3:139.
- Peramo A .Nanomedicine in Thrombosis. J Nanomedic Nanotechnol. 2012; 3:e106.
- Abdelhalim MAK, Mady MM, Ghannam MM .Physical Properties of Different Gold Nanoparticles: Ultraviolet-Visible and Fluorescence Measurements. J Nanomed Nanotechol. 2012; 3:133.
- Nikalje AP. Nanotechnology and its Applications in Medicine. Med chem..2015; 5:081-089.
- Komano Y, Yagi N, Nanki T. Joint-Targeting Drug Delivery System for Rheumatoid Arthritis: siRNA Encapsulated Liposome. Pharm Anal Acta.2015; 6:352.
- Lee JH, Ivkov R, Blumenthal R .Magnetically Triggered Drug Release from Liposome Embedded Gel. J Nanomedine Biotherapeutic Discov.2014; 4:130.
- Hu D, Tang S, Peng H, Wang Q. The Bright Future of Liposome Mediated Drug Delivery. Biochem Physiol.2015; 4: e133.
- Jigar N Shah, Hiral J Shah, Anastasia Groshev, Anjali A Hirani, Yashwant V Pathak et al. Nanoparticulate Transscleral Ocular Drug Delivery. J Biomol Res Ther.2014; 3:116.
- Malika V, Kohli K, Chaudhary H, Kumar V. Nano-Carrier for Accentuated Transdermal Drug Delivery. J Develop Drugs.2014; 3:121.
- Silva HR, Luz GM, Satake CY, Correa BC, Sarmento VHV, et al. Surfactant-based Transdermal System for Fluconazole Skin Delivery. J Nanomed Nanotechnol.2014; 5:231.
- Nagai N, Ito Y. A New Preparation Method for Ophthalmic Drug Nanoparticles. Pharm Anal.2014; Acta 5:305.
- Singh M, Kumar M, Manikandan S, Chandrasekaran N, Mukherjee A, et al. Drug Delivery System for Controlled Cancer Therapy Using Physico-Chemically Stabilized Bioconjugated Gold Nanoparticles Synthesized from Marine Macroalgae, Padina Gymnospora. J Nanomed Nanotechol.2014; S5:009.
- Kondrashina OV. A Targeted Drug Delivery System of Gd3+ for Neutron Capture Therapy against Cancer is Metalorganic Magnetic Nanoparticles. J Nanomedine Biotherapeutic Discov.2013; 3:116.
- Sandeep Kumar V .Magnetic Nanoparticles-Based Biomedical and Bioanalytical Applications. J Nanomed Nanotechol. 2013; 4: e130.
- Levitsky IA. Carbon Nanotube Hybrids for Renewable Energy. J Nanomed Nanotechol . 2012; 3:e117.
- Naga Anusha P, Siddiqui A .Nanomedical Platform for Drug Delivery. J Nanomedic Nanotechnol . 2011; 2:122.
- Nanjwade BK, Derkar GK, Bechra HM, Nanjwade VK, Manvi FV .Design and Characterization of Nanocrystals of Lovastatin for Solubility and Dissolution Enhancement. J Nanomedic Nanotechnol. 2011; 2:107.
- Salim N, Basri M, Abd. Rahman MB, Abdullah DK, Basri H, et al. Phase Behaviour, Formation and Characterization of Palm-Based Esters Nanoemulsion Formulation containing Ibuprofen. J Nanomedic Nanotechnol. 2011; 2:113.