Types of Cancer and Surgery in Rats (Rattus norvegicus) | Open Access Journals

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Types of Cancer and Surgery in Rats (Rattus norvegicus)

Raja Ramesh GV*

Department of Biochemistry, GITAM University, Andhra Pradesh, India

*Corresponding Author:
Raja Ramesh GV
Department of Biochemistry, GITAM University
AP, India.
E-mail: rajaramesh369@gmail.com

Received date: December 15, 2016; Accepted date: December 16, 2016; Published date: December 17, 2016

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Cancer is a disease, which involves abnormal cell growth. It is caused due to mutation in cells. The cell undergoes uncontrolled division. It has the potential to invade or spread to other parts of the body. Based on the type of tumors, cancer is benign and malignant and from origin it is of different types. Along with humans, cancer is also spread to the animals. They also contain different types based on the origin. Cancer is rife in the animal kingdom. For many, the mortality rate is similar to that suffered by humans. The tumor suppressor gene (p53) will helps to supress the cancer genes in humans along with in animals. Cancer is also prevalent in wild animals. Elephants have less chance to effect because they contain trillion of cells. The incidence of cancer in humans is much higher than the incidence of cancer in elephants and whales called as “Peto's paradox”.


Cancer, Benign, Tumor, Surgery


Rats are genetically predisposed to a high incidence of tumors and cancers. Some tumors may be malignant while others are benign. Mostly in rats, cancer is benign tumors. In all benign cases, we can remove the tumor to reduce the fatalities of rats [1-5].

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Types And Symptoms

1. Keratocanthomas: Benign tumors of the skin that develop in the chest, back or tail.

2. Mammary Fibroadenomas: The most common type of reproductive tumors in rats. It can found in the mammary (breast) tissue. It can found in both female and male rats [31-38].

3. Mammary Adenocarcinomas: Malignant tumors that are found under the skin anywhere on the underside of the body, from the head to the tail, as rats have widely effected mammary (breast) tissue. Typically these tumors are soft, round, or somewhat flat growths that can be moved [39-45].

4. Pituitary Gland Tumors: Observed common in female rats. Due to the position of the tumor, symptoms include head tilting and depression. These tumors may leads to sudden death.

5. Testicular Tumors: Found in the testes of male rats [46-52].

6. Zymbal’s tumors: Found at the base of the ear in older rats; they are relatively infrequent [53-61].


Rats by nature are very susceptible to the development of tumors. Some are more common than others [62-69]. For example, mammary adenocarcinomas are common in rats because of their widely distributed mammary tissue. Tumors of the pituitary gland increase in occurrence in relation to increased consumption of high-calorie foods [70-75].


Tumors growths that can be seen or felt externally are the easiest to diagnose [76-80]. Tumors that occur in the internal organs can only be diagnosed with the assistance of X-rays and other scans.


Benign tumor can be remove tumors from rats through surgeries, and only a few turned out to be malignant. Benign mammary tumors can be removed by minor surgery. But even huge tumors can be removed as long as your rat is otherwise in good health and steps are taken to prevent shock. The smaller the tumor, the more easily it can be removed. Mammary tumors and fibromas are just under the skin, the surgery to remove them is minor, as opposed to major surgery which enters a body cavity, and rats usually recover quite quickly [81-86]. In fact, even rats with congestive heart failure appear to tolerate surgery well if their symptoms are controlled with medications.

Other Non-Surgical Treatments

Cannabis/oregano ointment that has been successfully treating a cancerous tumor that broke through the skin for 6 months. A compound that has been shown to both treat and prevent cancerous mammary tumors induced (not natural tumors) in the lab is conjugated linoleic acid (CLA). This compound has even been shown to help rats lose weight [87-90].

Shark cartilage can help to prevent the formation of new blood vessels, which tumors need to grow. Nitroxoline is an antibiotic that has been used to treat urinary infections in Europe for about fifty years. It works by blocking the ability of bacteria to replicate. In 2010 researchers at Johns Hopkins School of Medicine discovered that it also can help to slow the growth of tumors by blocking the formation of new blood vessels. Giving nitroxoline to mice with either mammary cancer or bladder cancer found that the tumors shrank by 50 to 60%. Treatment with prednisone for some cancers other than mammary cancer can slow their growth [91-95].

Rat Used as a Laboratory Model

The primary focus of rat cancer research is the species Rattus norvegicus which is originated in Asia. The history of rats in biomedical research is quite extensive [96-98]. For over 150 years scientists have employed rats as models for many topics. In fact, the first domesticated laboratory mammal is believed to be the rat. It is mostly used in medical research, because rats are larger than mice, there are many areas of investigation for which they are easier to use than mice; for example, blood pressure measurements and serial blood samples are more readily obtained in rats than in mice [99-100].


Rats have certain advantages as models of disease, and they are one of the most widely used organisms in medical research. They have a high importance in cancer research. Rat is also a useful model in basic cancer research. Several rat models of monogenic (Mendelian) human hereditary cancers are available. Some were obtained spontaneously, while others were generated either by mutagenesis of tumor suppressor genes or by transgenesis of activated oncogenes.