An Analysis of the Variability of Haemodynamic Parameters in Patients with Ischaemic Heart Disease Undergoing Dental Surgery: A Randomised Clinical Trial
Background: The aim of this study was to compare the influence of 2% lidocaine with and without a vasoconstrictor agent (0.00125% norepinephrine) on the haemodynamic parameters of patients with ischaemic heart disease during basic dental surgery procedures.
Materials and Methods: In total, 120 adult patients were enrolled into two groups: (1) patients with detected and treated ischaemic heart disease and (2) healthy patients not taking any medications. Each group was additionally randomly assigned to an experimental group, which received 4.0 mL of 2% lidocaine containing 0.00125% norepinephrine prior to surgery, or a control group, which received 4.0 mL of 2% lidocaine without norepinephrine. Haemodynamic parameters (systolic blood pressure, diastolic blood pressure, heart rate and blood oxygen saturation) were measured three times: before surgical procedures and 5 and 20 minutes after administration of local anaesthesia. Before treatment, patients were asked to complete a general health survey.
Results: No statistically significant differences were noted in systolic blood pressure, diastolic blood pressure, heart rate and blood oxygen saturation between experimental and control groups.
Conclusion: The addition of 0.00125% norepinephrine to 4.0 mL of 2% lidocaine for local anaesthesia during basic dental surgery procedures exerts no significant effect on the haemodynamic parameters of patients with coronary artery disease.
Anna Godzieba, Krzysztof Safranow, Tomasz SmektaÅa, Katarzyna SporniakTutak