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conferenceseries.com
RRJOMS | Volume 5 | Issue 4 | July, 2017
July 27-29, 2017 Vancouver, Canada
10th International Conference on
Emerging Materials and Nanotechnology
Gold-based emerging nanomaterials for imaging and experimental cancer therapy
Anton Liopo1, 2, Katherinne I Requejo2, Khaled Habiba1 and Sunil Krishnan1
1University of Texas, USA
2Rice University, USA
Gold nanoparticles of different shape and size have been designed and applied as contrast-enhancing agents for various imaging
techniques: optical coherence tomography, fluorescence imaging, optical microscopy, photoacoustic imaging and sensing; and
recently, for experimental cancer therapy as enhancers of thermal and radiation modes. In this presentation, we are focusing on
different sides of gold nanorods (GNRs) applications, as well as their synthesis, functionalization, and specific targeting. The role of
GNRs in comprehensive cancer diagnostics and treatment was analyzed and created the novel GNRs’ modifications of wide-ranging
aspects ratio, size with high yield and quality. The GNRs were assessed by their toxicity for altered categories, such as amount of gold,
surface area, optical density of their solutions and number of particles. GNRs have been reviewed as contrast agents with near-infrared
absorption as highly efficient transformers of light energy into heat. Here, we present the use of GNRs as plasmonic nanoparticles for
selective photothermal therapy of human acute and chronicle leukemia cells using a near-infrared laser. We have investigated GNRs
as potential enhancers of radiotherapy. We have demonstrated high impact of external surface chemistry, role of molecules size and
thickness of surfactant layer for damage of cancer cells by electromagnetic radiation. GNRs were evaluated as theranostic agents for
imaging, photothermal and radiation modalities. The results may impact pre-clinical GNRs’ applications, molecular imaging, and
quantitative sensing of biological analytes.
Biography
Anton Liopo has completed his PhD degree from the Institute of Physiology the National Academy of Science (NAS), Belarus. He later joined the Institute of
Biochemistry of NAS of Belarus as Senior Scientist, Associate Professor, and eventually the Director of Government Program. After moving to the United States,
he obtained trainings in Molecular Biology in Department of Internal Medicine and Nanotechnology of Center for Biomedical Engineering at the University of Texas,
Medical Branch at Galveston. He worked as lead Scientist for Nanobiotechnology Program in TomoWave Laboratories Inc. Currently, he is doing investigations in
Center for Radiation Oncology Research, UT MD Anderson Cancer Center, where he is aiming on novel nanocomposites for enhancement of cancer radio-therapy
and he is also a Visiting Scientist in Department of Chemistry of Rice University. He is a regular reviewer and Member of several Editorial Boards of scientific
journals and has more than 75 peer-reviewed publications, including monograph, book chapters and patents.
Anton Liopo et al., Res. Rev. J Mat. Sci. 2017
DOI: 10.4172/2321-6212-C1-002