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conferenceseries
.com
RRJOMS | Volume 5 | Issue 4 | July, 2017
July 27-29, 2017 Vancouver, Canada
10
th
International Conference on
Emerging Materials and Nanotechnology
Rapid conversion of lipids into biopolymers and conjugates
Aman Ullah, Muhammad Arshad
and
Shimiao Zhang
University of Alberta, Canada
S
olvent free conversion of canola oil and fatty acid methyl esters (FAME's) derived from canola oil and waste cooking oil under
microwave irradiation demonstrated dramatically enhanced rates. The microwave-assisted reactions lead to the most valuable
terminal olefins with enhanced yields, purities and dramatic shortening of reaction times. Various monomers/chemicals were
prepared in high yield in very short time. The complete conversions were observed at temperatures as low as 50ºC within less than
five minutes. The products were characterized by GC-MS, GC-FID and NMR. The prepared monomers were further converted into
biopolymer and characterized in detail. In another approach, amphiphilic ABA type PEG-Lipid conjugated macromolecules have
been synthesized using the copper-catalyzed azide-alkyne cycloaddition commonly termed as “click chemistry. Characterization of
the conjugates has been carried out with the help of 1H-NMR, FTIR and GPC.The conjugates were evaluated for the encapsulation and
release of an anticonvulsant drug (carbamazepine) as a hydrophobic drug model in the study. The micellization, drug encapsulation
and release behavior of macromolecules was investigated by dynamic light scattering (DLS), transmission electron microscope
(TEM) and fluorescence spectroscopy. From the results, it has been concluded that the nanoparticles had different average sizes due
to different ratio of hydrophilic contents in the conjugate backbone. The amphiphilic particle size and structure could be altered by
changing the ratio of hydrophilic and hydrophobic contents. The
in vitro
drug encapsulations highlighted that all the drug-loaded
micelles had spherical or near-spherical morphology.
In vitro
drug release study showed the controlled release of hydrophobic drug
over a period of 50 hours. The results indicate that there is great potential of renewable lipid-based micelle nanoparticles to be used
as hydrophobic drug carriers.
Biography
Aman Ullah received his PhD (with distinction) in Chemical Sciences and Technologies in 2010 at the University of Genova, Italy by working together at Southern
Methodist University, USA. He is currently working as an Assistant Professor at the Department of Agricultural, Food and Nutritional Science, University of Alberta.
He has published more than 25 papers in reputed journals and 3 patents/patent applications. He was named a Canadian Rising Star in Global Health by Grand
Challenges Canada.
amanullah@ualberta.caAman Ullah et al., Res. Rev. J Mat. Sci. 2017
DOI: 10.4172/2321-6212-C1-002