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.com
November 13-15, 2017 | Las Vegas, USA
14
th
International Conference and Exhibition on
Materials Science and Engineering
RRJOMS | Volume 5 | Issue 7 | November, 2017
Colorimetric contact lens type sensor consisting of cerium oxide nanoparticles and glucose oxidase for tear
glucose detection
Sijin Park
1
, Woo Ri Bae
1
, Kang Moo Huh
2
and
Dong Yun Lee
1
1
Hanyang University, Republic of Korea
2
Chungnam National University, Republic of Korea
A
contact lens is ideal to monitor glucose levels in tear. We designed a contact lens-based biosensor comprised of glucose oxidase
(GOX) and cerium oxide nanoparticle (CNP) to detect glucose levels in tear. GOX catalyzes the oxidation of glucose to hydrogen
peroxide (H
2
O
2
) and gluconolactone. Then, CNP catalyzes the reduction of H
2
O
2
. At this moment, Ce
3+
being colorless shift to Ce
4+
state that is shown yellow color. Glucose levels can be determined by analyzing the change of color. B value of RGB color is used to
determine glucose levels, being shown the correlation with glucose concentration. To confirm the synthesized CNP structure, we
perform the XPS, XRD, HR-TEM. GOX is immobilized on a modified-CNP using PEG spacer; it is CNP-PEG-GOX. The formation
of CNP-PEG-GOX is determined via quantitative analysis of GOX. The contact lens sensor maintains its mechanical properties
compared with HEMA contact lens. and has correlation with glucose levels in buffer and artificial tear.
Biography
Sijin Park graduated from Hanyang University, Department of Bioengineering at the age of 24, and progressed to master’s course. She is mainly working on diabetes. In par-
ticularly, she studies the development of glucose sensors for the management of blood glucose in diabetic patients. She has identified the disadvantages of the Fingerprick
test, which is currently the most commonly used method, and invented a breakthrough method to overcome the drawbacks. Instead of measuring blood in the fingertips,
she has developed a method for sensing blood glucose non-invasively through glucose concentration in the tear.
santiagom@naver.comSijin Park et al., Res. Rev. J Mat. Sci. 2017, 5:7
DOI: 10.4172/2321-6212-C1-012