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Pathology 2018 Research & Reviews: Journal of Medical and Health Sciences
ISSN: 2319-9865 Page 45
October 08-09, 2018
Edinburgh, Scotland
17th International Conference on
Pathology & Cancer
Epidemiology
Wilhelm Carl Hueper (1894-1978), a German-born and
trained medical practitioner, emigrated to the US in 1923.
In the 1930s, he was a pathologist at the Dupont synthetic
polymer works and published articles on industrial hygiene.
In 1942, he published his first major work on occupational
carcinogenesis [1], proposing that a large proportion of non-
industrial as well as industrial human cancers are caused by
man-made chemicals. In 1948, he was appointed Director of
the Environmental Carcinogenesis Section of the NIH. Four
later major works [2-5] used extensive epidemiological data
to support his opinion that industrial chemicals cause most
of the cancers in the general population. His life-time oeuvre
and influence have been discussed [e.g. 6-9], but only limited
attention has been paid to his views on tobacco smoking and
trauma as causes of cancer.
This paper reviews issues in the pathology and epidemiology
of these topics as discussed in Hueper’s main works [1-5].
1. Hueper WC. “Occupational Tumors and Allied
Diseases”, Charles C Thomas, Springfield Ill, 1942.
2. Hueper WC. Environmental and Occupational Cancer.
Public Health Reports (Federal Security Agency)
Suppl 209, 1948.
3. Hueper WC. “A Quest into the Environmental Causes of
Cancer of the Lung”. Public Health Service Publication
No. 452, US Government Printing Office, Washington
DC, 1956.
4. Hueper WC. Conway WD. “Chemical Carcinogenesis
and Cancers”. Charles C. Thomas, Springfield IL, 1964.
5. Hueper WC. “Occupational and Environmental
Cancers of the Respiratory System”. Springer 1966.
6. Agran L. “The Cancer Connection”. St. Martin’s, New
York, 1977.
7. Proctor R. “Cancer Wars”, Basic Books, New York,
1995.
8. Michaels D. Int J Occupat Environ Health. 1:278-288,
1995.
9. Meister K. (ed). “America’s War on ‘Carcinogens’”.
American Council on Science and Health, New York,
2005.
Biography
Leon P Bignold is a Histopathologist interested in genomic mechanisms
of the histopathology and related features of tumors. He has published
18 papers, edited one volume “Cancer: Cell Structures, Carcinogens and
Genomic Instability”, Birkhäuser, 2006 and written two books “David Paul
Hansemann: Contributions to Oncology”, Birkhäuser, 2008; “Principles of
Tumors: a Translational Approach to Foundations”, Elsevier 2015 in this
area. His research interests are genomic explanations of the histopathol-
ogy and related phenomena of tumors.
Tobacco smoking and trauma in Wilhelm C Hueper’s concepts
of cancer causation
Leon P Bignold
University of Adelaide, South Australia
Leon P Bignold, RRJMHS 2018
Volume: 7