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Glycopeptides

Glycopeptides are considered antibiotics of pis aller for the treatment of life-threatening infections caused by relevant Gram-positive human pathogens, like Staphylococcus aureus, Enterococcus spp. and Clostridium difficile. The emergence of glycopeptide-resistant clinical isolates, first among enterococci then in staphylococci, has prompted research for second generation glycopeptides and a flurry of activity aimed toward understanding resistance mechanisms and their evolution. Glycopeptides are glycosylated non-ribosomal peptides produced by a various group of soil actinomycetes. they aim Gram-positive bacteria by binding to the acyl-d-alanyl-d-alanine (d-Ala-d-Ala) terminus of the growing peptidoglycan on the outer surface of the cytoplasmatic membrane

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