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A Brief Study on Hemorrhagic Septicemia

Karunasree P*

GITAM University, Visakhapatnam, India

*Corresponding Author:
Karunasree P
MBA, GITAM University
Visakhapatnam, Andhra Pradesh, India.
E-mail: [email protected]

Received date: 22/07/2016 Accepted date: 24/07/2016 Published date: 25/08/2016

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Hemorrhagic septicemia (HS), an intense, lethal and septicemic disease of cattle and wild oxen is caused by Pasteurella multocida, is vital in tropical locales of the world, particularly in African and Asian nations. The pervasiveness of sickness has been very much reported with dominating detachment of P. multocida serotypes B:2 and E:2. Routine strategies for recognizable proof, for example, serotyping, antibiogram, biotyping determination and pathogenicity and in addition sub-atomic techniques (P. multocida-particular polymerase chain response (PCR), a serogroup B-particular PCR test, multiplex capsular writing framework and circle interceded isothermal enhancement methods) and portrayal (restriction endonuclease analysis, randomly amplified polymorphic DNA analysis, repetitive extragenic palidromic PCR and enterobacterial repetitive intergenic consensus PCR analysis) are connected in parallel for quick epidemiological examinations of HS flare-ups. Albeit a few antibody definitions including alum encouraged, oil adjuvant and various emulsion immunizations are financially accessible, the mission for appropriate extensively defensive HS antibodies with durable safety is on the upsurge. Simultaneously, endeavors are being made to disentangle the secrets of the pathogen and its destructiveness components, pathogenesis and determinants of defensive invulnerability and in addition differences among strains of P. multocida. This survey highlights the advances in these different parts of HS.


Hemorrhagic Septicemia, P. multocida, Cattle, Dairy industries, Nasal release


Haemorrhagic septicaemia in cattle and buffaloes was previously known to be associated with one of two serotypes of P. multocida: B:2 and E:2 or 6:B and 6:E using different analytical systems [1-8]. The disease occurs mainly in cattle and buffaloes. It is an endemic disease mostly prevalent in African and Asian countries. As these continents mainly consist of Dairy industries, this disease is more prevalent in these areas than the European countries. Buffaloes are more susceptible to Haemorrhagic septicemia than any other animal [9-12].

Causative Organism

Pasteurella multocida is the causative organism which is causing Haemorrhagic septicemia in the cattle. P. multocida is a Gram-ve, non-motile bacterium which is sensitive to Pencillin. It causes a wide range of diseases in cattle mainly. This bacterium is a deadly organism which causes brain death in the cattle [13-15].

The serotyping techniques differentiate Pasteurella multocida into five capsular serogroups (A, B, D, E, and F) and 16 physical serotypes (1 to 16) [16-20]. The capsule and the liposaccharide are causing bacterial avoidance of phagocytosis and bacterial survival in the cattle. In the present study, we have built up a multiplex PCR test as a fast other option to the customary capsular serotyping framework.

Pasteurella is spread by means of direct contact, or by ingestion of food and water. Transmission of these is particularly effective when calves are swarmed or firmly bound (calf nursery). P. multocida is regularly connected with the more drawn out enduring instances of cow-like respiratory ailment [21-25]. The symptoms of this disease begin with melancholy, and diminished ravenousness. This advances to finish loss of hankering, cut head and hair, mucopurulent nasal release and a high fever and heavy breathing. If the treatment is not provided immediately, the lungs get infected which eventually leads to the death of the cattle.


Heating of Conductors

The main symptoms include high temperature, loss of weight and feeling feeble, nasal release, salivation and heavy breathing, with swellings in the throat region spreading to the brisket area and to the forelegs [26-30].

The clinical signs include a temporary determination is imperative since preventive measures to control the spread of the ailment are required quickly, without sitting tight for the vital research facility affirmation [31-36]. At the most punctual opportunity, in any case, proper material ought to be gathered and dispatched to the closest research center. The simple segregation of P. multocida does not imply that Hemorrhagic septicemia was analyzed. From one perspective it ought to be placed in the epidemiological connection also, then again the disconnected strain must be serotyped [37-38]. Bacillus anthracis, blackquarter and, more particularly rinderpest (because of its conceivable ramifications in universal creature wellbeing) ought to dependably be considered when researching sudden passing’s in dairy cattle and wild oxen.


The three important factors of this epidemic are:

1. Climatic conditions: The climatic conditions regularly the storms with high moistness and at times with high temperatures.

2. Dairy practices: Dairy practices includes lack of fodder and the pressures of the work that animals do e.g. agriculture animals, crowded nurseries, dirty farm lands.

3. Species of the animal: Buffalos and calves are more susceptible than any other dairy cattle to this disease.


A complete conclusion of HS depends on separation of P. multocida serotype B:2 or E:2 (or different less regular serotypes perceived by the OIE as bringing on HS) from the blood and tissues of a creature with commonplace signs [39-44]. Different other P. multocida serotypes can bring about HS-like malady in dairy cattle and water bison, which must be separated from traditional HS. The aloof mouse insurance test utilizing particular B:2 and E:2 insusceptible rabbit sera has been utilized as a part of Asia and Africa to recognize these serotypes [45-49]. The PCR methods are most achievable for use in endemic ranges and can be utilized with different examples, including blood, tissues, or microorganisms from juices or plate societies.

Treatment and Prevention

Cattle can be cured only if they have been treated in the very early phases of the attack. In Dairy farms, however, early detection and effective treatment are achieved only through regular checking temperatures of the animals. Generally chemotherapy resorts to either streptomycin or oxytetracycline managed by intramuscular course at genuinely high dose [50-56]. Penicillin, sulfonamides, tetracycline, chloramphenicol and ampicillin are also effective drugs to be administered [57-69]. Since hemorrhagic septicemia typically leads to acute death, control of the infection by treating them by using antibiotics and serum therapy has been futile and prevention is by vaccination [70-75].

Formaldehyde induced culture of P. multocida adsorbed on aluminum hydroxide gel is available for prophylactic vaccination against septicemia cows and buffaloes [76-82] with the following vaccination regimen:

Primary vaccination: Six months of age or above, followed by booster dose after one month.

Revaccination: Annually [83-88].


Pastuerella multocida can easily infect humans and so while dealing with the cases related to these, proper care and preventive measures should be taken [89-100]