Department of Pharmacognosy, Stanford University, Stanford, California, USA
Received: 29-May-2023, Manuscript No. JPRPC-23-99715; Editor assigned: 31-May-2023, PreQC No. JPRPC-23-99715 (PQ); Reviewed: 14-Jun-2023, QC No JPRPC-23-99715; Revised: 21-Jun-2023, Manuscript No. JPRPC-23-99715 (R); Published: 29-Jun-2023, DOI: 10.4172/2321-6182.11.2.007
Citation: Wheeler N. Exploring the Potential of Marine-Derived Polyphenols and Therapeutic Agents. J pharmacogn phytochem.2023;11:007.
Copyright: © 2023 Wheeler N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided the original author and source are credited.
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Polyphenols are a class of natural compounds with diverse biological activities that have been widely studied for their potential health benefits. While many polyphenols are abundant in terrestrial plants, recent research has focused on the identification and characterization of polyphenols derived from marine organisms. Marine-derived polyphenols exhibit unique chemical structures and pharmacological properties, making them promising candidates for drug discovery and development. The potential of marine-derived polyphenols as therapeutic agents, with a focus on their bioactive properties and mechanisms of action. This study discusses about the challenges and strategies for drug development using marine-derived compounds and the implications for future research in this field. Marine-derived polyphenols are extracted from a variety of marine organisms, including algae, sponges, and marine invertebrates. Their chemical structures are diverse and include flavonoids, phenolic acids, and stilbenes among others. Marine-derived polyphenols exhibit unique structural features and possess unique bioactive properties, such as antioxidant and anti-inflammatory activity.
Bioactive properties and mechanisms of action
Marine-derived polyphenols exhibit a variety of bioactive properties that make them promising therapeutic agents. They have been shown to possess strong antioxidant and anti-inflammatory properties which play a major role in their potential health benefits. Additionally, they have been shown to have anti-cancer, cardiovascular, and neuroprotective effects. The mechanisms of action of marine-derived polyphenols are diverse and include scavenging of reactive oxygen species, modulation of cell signaling pathways, and inhibition of the expression of pro-inflammatory genes. These unique mechanisms of action suggest the potential of these compounds as therapeutic agents for the prevention and treatment of many diseases.
Challenges and strategies for drug development
Despite the potential health benefits of marine-derived polyphenols, drug development using these compounds faces several challenges. One of the main challenges is the difficulty in sourcing and isolating these compounds from their natural sources. Additionally, many of these compounds have low bioavailability and require chemical modifications to improve their pharmacokinetic properties. To overcome these challenges, strategies have been developed for drug development using marine-derived compounds. These strategies include the use of synthetic chemistry to modify the structure of these compounds, as well as biotechnological approaches to produce them in large quantities.
Future directions and implications for drug development
The identification and characterization of marine-derived polyphenols represent a promising area for future drug marine-derived polyphenols have a wide range of potential uses in both preventive and therapeutic applications. Some of the potential uses of marine-derived polyphenols include:
• Anti-inflammatory and antioxidant properties: Marine-derived polyphenols have strong antioxidant and anti-inflammatory properties which have potential applications in the treatment and prevention of many chronic diseases.
• Anti-cancer properties: Marine-derived polyphenols have been shown to have anti-cancer effects and have potential applications in the prevention and treatment of various types of cancer.
• Cardiovascular health: Marine-derived polyphenols have been shown to have a protective effect on cardiovascular health by reducing inflammation, improving blood flow, and reducing blood pressure.
• Neuroprotection: Marine-derived polyphenols have been shown to have neuroprotective effects, which suggests their potential applications in the treatment of neurodegenerative disorders.
• Photo protective substances: Marine-derived polyphenols have also been investigated for their potential photo protective properties and can be used to provide the skin protection from harmful UV radiation.