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Green Extraction Techniques in Herbal Pharmacognosy

Radhika S. Iyer*

Department of Pharmacognosy and Phytopharmaceutical Sciences, Manipal College of Pharmaceutical
Sciences, Manipal, India

*Corresponding Author:
Radhika S. Iyer
Department of Pharmacognosy and Phytopharmaceutical Sciences, Manipal College of Pharmaceutical
Sciences, Manipal, India
E-mail: radhika.iyer@manipal.edu.in

Received: 05-Mar-2025, Manuscript No. jprpc-25-169377; Editor assigned: 7-Mar-2025, Pre-QC No. jprpc-25-169377 (PQ); Reviewed: 18-Mar-2025, QC No jprpc-25-169377; Revised: 25-Mar- 2025, Manuscript No. jprpc-25-169377 (R); Published: 30-Mar-2025, DOI: 10.4172/2347-1234.13.008

Citation: Radhika S. Iyer, Green Extraction Techniques in Herbal Pharmacognosy. J Pharmacogn Phytochem. 2025.13.008.

Copyright: © 2025 Radhika S. Iyer, this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Research & Reviews: Journal of Pharmacognosy and Phytochemistry

Abstract

Green extraction refers to the development of sustainable, efficient, and environmentally friendly methods for isolating bioactive compounds from medicinal plants. With increasing concern over toxic solvents, energy usage, and environmental waste, novel green extraction techniques offer safer alternatives. This article reviews the principles, types, and applications of green extraction methods in herbal pharmacognosy, with emphasis on phytochemical yield, safety, and industrial scalability.

INTRODUCTION

Conventional solvent-based extraction techniques, while effective, often involve high energy consumption, hazardous solvents, and long processing times. Green extraction prioritizes methods that reduce solvent use, energy requirements, and environmental impact while improving yield and preserving thermolabile phytochemicals. These techniques are gaining prominence in the production of herbal extracts, nutraceuticals, and standardized phytopharmaceuticals [1].

Principles of Green Extraction

  • Use of Safe Solvents: Ethanol, water, supercritical COâ??
  • Energy Efficiency: Reduce heat and time requirements
  • Waste Minimization: Recoverable solvents, minimal effluent
  • Selectivity and Yield: Target specific compounds
  • Scalability: Suitable for lab to industrial production

Major Green Extraction Techniques

Technique

Description

Advantages

Supercritical Fluid Extraction (SFE)

Uses supercritical COâ?? at high pressure

Non-toxic, solvent-free, high selectivity

Microwave-Assisted Extraction (MAE)

Microwaves heat plant matrix internally

Fast, high yield, minimal solvent

Ultrasound-Assisted Extraction (UAE)

Acoustic cavitation disrupts plant cells

Energy-efficient, enhances mass transfer

Pressurized Liquid Extraction (PLE)

High temp & pressure with water/ethanol

Accelerates extraction, less solvent

Enzyme-Assisted Extraction (EAE)

Uses cellulase, pectinase to break cell walls

Mild, improves release of actives

Natural Deep Eutectic Solvents (NADES)

Biocompatible solvent systems (e.g., cholineâ??glucose)

Sustainable, tunable for polarity

Applications in Herbal Extraction

Plant

Target Compound

Green Method

Curcuma longa

Curcumin

MAE, UAE

Andrographis paniculata

Andrographolide

SFE

Ginkgo biloba

Flavonol glycosides

PLE

Ocimum sanctum

Eugenol

UAE

Camellia sinensis

Catechins

EAE

Green methods often improve extraction efficiency and preserve compound integrity.

Comparative Analysis with Traditional Techniques

Parameter

Conventional Solvent Extraction

Green Extraction

Solvent Use

High (often toxic)

Minimal, safe

Energy Use

High

Moderate to low

Selectivity

Broad, non-specific

Targeted

Extraction Time

Long (hours)

Short (minutes)

Safety

Flammable, hazardous

Eco-friendly

Scalability

Established

Emerging

Regulatory and Industry Trends

  • Phytopharmaceutical Guidelines: Favor green technologies for GMP compliance.
  • AYUSH and WHO Advocacy: Encourage eco-safe production of traditional medicines.
  • Cosmeceuticals and Nutraceuticals: Prefer solvent-free extracts for label claims.
  • Green Certifications: Encourage use of biodegradable solvents and clean energy sources.

Challenges in Implementation

  • High Initial Costs: Equipment for SFE, MAE is expensive.
  • Optimization Required: Parameters like pressure, time, and frequency must be tailored.
  • Limited Standardization: Protocols vary across labs and plant species.
  • Skill and Training: Requires technical expertise in instrumentation.

Future Outlook

  • Integration of Green Methods: Hybrid techniques (e.g., UAE + EAE) to maximize efficiency.
  • AI-Driven Optimization: Machine learning for predictive modeling of extraction yields.
  • Waste Valorization: Using by-products for bioenergy or secondary metabolite recovery.
  • Green Solvent Innovation: Ongoing research in ionic liquids and bio-based solvents.

CONCLUSION

Green extraction is revolutionizing the field of herbal pharmacognosy by offering sustainable, efficient, and consumer-safe alternatives to conventional methods. Though challenges remain in cost and scalability, advances in green chemistry and extraction technology are making these methods increasingly accessible to academia, industry, and regulatory bodies.

References

  1. Chemat F, et al. Green extraction of natural products: Concept and principles. Int J Mol Sci. 2012;13(7):8615â??8627.
  2. Wang L, et al. Emerging solvent-free extraction technologies in herbal medicine. Phytochem Anal. 2021;32(4):547â??562.
  3. Azmir J, et al. Techniques for extraction of bioactive compounds from plant materials: A review. J Food Eng. 2013;117(4):426â??436.
  4. Chemat F, et al. Review of green food processing techniques. Innov Food Sci Emerg Technol. 2017;41:357â??377.
  5. Zabot GL, et al. Supercritical fluid technologies for phytochemical extraction. J Supercrit Fluids. 2020;160:104800.