Commentary Open Access

Advances in Animal Models of Lumbar Ligamentum Flavum Hypertrophy

Abstract

Ligamentum Flavum Hypertrophy (LFH) is a key pathological factor in Lumbar Spinal Stenosis (LSS), driven by mechanisms like mechanical stress and collagen deposition. Although animal models are used to study LFH, they still face limitations in biological authenticity and clinical translation. This commentary reviews the advantages and limitations of surgical and non-surgical modeling approaches, proposing potential optimization strategies. It also explores future research directions to improve LFH models and enhance clinical outcomes.

Long Chen,Wanxia Zhang, Weifeng Guo, Dongchun You, Yu Zhang*

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