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Research Article Open Access

Formulation and Evaluation of Mucoadhesive Buccal Film of Lisinopril.


The mucoadhesive buccal film of Lisinopril were prepared by using various polymers like HPMC K4M, sodium CMC, PVP K30, eudragit RL 100, carbopol 934 by solvent casting method and evaluated for physical appearance, thickness, weight uniformity, folding endurance ,percentage swelling index, percentage moisture content, drug diffusion studies and drug content estimation.Among all formulation, buccal film prepared with 4% HPMC K4M,0.5% PVP K30 1% Sodium CMC and 5% tween 80 as surfactant exhibited better drug release, drug content estimation and maximum percentage of swelling index. The drug release could be extended up to 8 hr and a drug release of 98.41% was observed. FTIR studies revealed that drug and excipients are compatible. Stability study of selected optimised formulations were done as per ICH guidelines for 1 month, which revealed that no significant change with respect to the evaluations conducted before stability charging.

Ann Rose Augusthy, Vipin KV, Sarath Chandran C, Thushara MV, Shahin Muhammed TK

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