e-ISSN: 2321-6182 p-ISSN: 2347-2332

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article Open Access

In vitro antimalarial activity of methanol extract and fractions of whole plant of Centaurea perrottetii D.C

Abstract

Malaria is a major public health problem affecting not less than 40 % of the world’s population. The whole plant of Centaurea perrottetii DC is used in traditional medicine as anti-malarial, anti-gonorrhea and anti-syphilis agent. The aim of this study is to evaluate the in vitro antimalarial effect of C. perrottetii using β – hematin formation assay. The powdered whole herb (2.1 kg) of the plant was extracted with 90 % methanol and the resulting crude methanol extract (CME) was partitioned into n-hexane, chloroform, ethylacetate, n-butanol and residual aqueous fractions. The CME and its fractions exhibited significant antimalarial activity; the highest percentage inhibition of the β B hematin formation exhibited by the extract and fractions ranges from 98.66 – 99.64 % at 0.008 mg/mL which was higher than that exhibited by the standard drug, CQ (97.75 %). The IC50 values of the extract ranges from 0.0112 - 0.0114 mg/mL while CQ had 0.0114 mg/mL. The whole plant of C. perrottetii has demonstrated good antimalarial activity, thereby validating the ethnobotanical claim of the use of the plant in treatment of malaria. Alebiosu C. O

To read the full article Download Full Article

ritzz