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Research Article Open Access
In vitro antimalarial activity of methanol extract and fractions of whole plant of Centaurea perrottetii D.C
Malaria is a major public health problem affecting not less than 40 % of the worldâs population. The whole plant of Centaurea perrottetii DC is used in traditional medicine as anti-malarial, anti-gonorrhea and anti-syphilis agent. The aim of this study is to evaluate the in vitro antimalarial effect of C. perrottetii using Î² â hematin formation assay. The powdered whole herb (2.1 kg) of the plant was extracted with 90 % methanol and the resulting crude methanol extract (CME) was partitioned into n-hexane, chloroform, ethylacetate, n-butanol and residual aqueous fractions. The CME and its fractions exhibited significant antimalarial activity; the highest percentage inhibition of the Î² B hematin formation exhibited by the extract and fractions ranges from 98.66 â 99.64 % at 0.008 mg/mL which was higher than that exhibited by the standard drug, CQ (97.75 %). The IC50 values of the extract ranges from 0.0112 - 0.0114 mg/mL while CQ had 0.0114 mg/mL. The whole plant of C. perrottetii has demonstrated good antimalarial activity, thereby validating the ethnobotanical claim of the use of the plant in treatment of malaria.
Alebiosu C. O