Research Article Open Access

Optimization and Evaluation of Floating Drug Delivery System for Metronidazole.

Abstract

The present investigation concerns the development of Floating Drug Delivery System (FDDS) of Metronidazole, which are designed to increase the gastric residence time, thus prolonging the drug release with localized drug action. Hydroxy propyl methyl cellulose K4M (HPMC) used as polymer and drugs to polymer ratio used to prepare FDDS by wet granulation technique. The prepared FDDS were evaluated as per Pharmacopoeia and other standard references. The drug-polymer ratio, HPMC, different diluents and gas generating agents were found to influence the drug release and floating properties of the prepared FDDS. The floating properties and drug release characteristics were determined for the prepared FDDS in 0.1N HCL as dissolution media. All the FDDS formulations showed good in-vitro floating properties with an optimum concentration of gas generating agents, sodium bicarbonate and citric acid. The rate of drug release decreased with increased polymer concentration. It was found that HPMC viscosity had a significant impact on the drug release from the prepared FDDS. The decrease in the release rate was observed with an increase in the polymeric system. HPMC K4 M along with microcrystalline cellulose as diluents was found to be beneficial in improving the drug release rate and floating properties. Regression analysis of drug dissolution profiles on the basis of Higuchi’s and zero order indicated that diffusion is the predominant mechanism controlling the drug release.

Chetan Ghulaxe, Mousumi Kar Pillai, and Sujit Pillai

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