e-ISSN: 2321-6182 p-ISSN: 2347-2332
Plant Alkaloids: Classification, Biosynthesis, Pharmacological Activities, and Therapeutic Applications
Plant alkaloids constitute a diverse and structurally complex group of nitrogencontaining secondary metabolites that are widely distributed in the plant kingdom. These compounds are primarily derived from amino acids and are known for their pronounced physiological and pharmacological effects on humans and animals. Alkaloids have played a central role in the development of modern medicine, with several clinically important drugs such as morphine, quinine, vincristine, and atropine originating from plant sources. This article presents a comprehensive overview of plant alkaloids, including their sources, classification, biosynthesis, pharmacological properties, and therapeutic applications. The role of modern analytical techniques in alkaloid identification and quality control is also discussed. In addition, challenges such as toxicity, variability, and sustainability are critically examined. The integration of traditional knowledge with modern scientific approaches is essential for unlocking the full therapeutic potential of plant alkaloids and ensuring their sustainable utilization in drug discovery and development.
H. Yuki Tanaka
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