Preparation and Evaluation of Combination Tablet Containing Paracetamol and Ginger Powder and Its Extract.
The present study has been aimed to develop a tablet containing paracetamol in which ginger is incorporated to prevent the side effect of paracetamol like nausea and vomiting. In addition ginger contains starch, which acts as disintegrant. Granules were prepared by inclusion of ginger extract in A and B formulation and while ginger powder is present in C and D formulations. Granules were evaluated for particle volume, density and flow properties. Granules were compressed and tablets were evaluated for thickness, hardness, friability, and disintegration studies. The tablet hardness were generally higher with the ginger starch, an indication that lower concentration of ginger could be used to achieve the same level of binding. Tablets were further tested for dissolution studies, which showed better release of drug and drug content. Formulation C was found to be most effective as it decreases the concentration of starch, talc and magnesium stearate requirements.