The Nanotechnological Approach in Treatment of Drug Addiction
Drug addiction is a major health concern worldwide in which addiction plays major role. Addiction is caused by activation of the dopaminergic pathway within the brain. Initially individuals will take drugs based upon their interest, however using continuously will result in changes that make a dependant person out of control and they will be addicted to the particular drugs. On the other hand Nanotechnology is a scientific endeavour, in which there is utilization and creation of materials on the nanometer scale. The sector of engineering is presently undergoing development in many areas. The technology is anticipated to make innovations and play an important role in numerous medical applications. Here this article tends to introduce an engineering science approach which makes utilization of gold nanorod-DARPP-32 siRNA (short interfering RNA) complexes called as nanoplexes that concentrate on this dopaminergic signal pathway within the brain. The shift within which there is an interaction between localized longitudinal plasmon resonance peak of gold nanorods (GNRs) and siRNA. There is uptake of those nanoplexes in dopaminergic neurons in vitro during plasmonic increased dark field imaging. There is no determined toxicity with cistron silencing of the nanoplexes within these cells was proven by the reduction in the expression of key proteins like DARPP-32, ERK, and PP-1. In vitro model of the blood–brain barrier (BBB) nanoplexes were shown to transmigrate. So, these nanoplexes utilizing brain-specific delivery of acceptable siRNA seems to be fitted for therapy of dependency and other brain diseases. Nanotechnology has associate increasing impact within the health care industry not only in diagnostic and therapeutic areas and also in the delivery targeted into specific sites and across some complicated biological barriers.
Anusha Narise, Neelima Bondada, Divya Datla, Siddhartha Lolla, Santhoshi Gamini and Jyothi Bonam.