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Hydroxyapatite–heparin–BMP-2 on modified titanium surfaces enhances the efficacy of bone formation and osseointegration: In vitro & in vivo study

10th International Conference on Emerging Materials and Nanotechnology

July 27-29, 2017 Vancouver, Canada

Deok-Won Lee and Sung ok Hong

Kyung Hee University, South Korea
Catholic Kwandong University, South Korea

ScientificTracks Abstracts: Res. Rev. J Mat. Sci

DOI: 10.4172/2321-6212-C1-002


Introduction: In the present study, surface-modified Ti samples with hydroxyapatite (HAp) and heparin (Hep) bone morphogenetic protein-2 (BMP-2) complex (Ti/HAp/Hep/BMP-2) were prepared and the effects of the samples on the enhancement of bone formation and osseointegration in-vitro and in-vivo were investigated, as compared to Ti/HAp and Ti/Hep/BMP-2. Methods & Materials: Surface-modified titanium (Ti) samples with hydroxyapatite (HAp) and heparin (Hep)–bone morphogenetic protein-2 (BMP-2) complex (Ti/HAp/Hep/BMP-2) were prepared, and their efficacies on the enhancements of bone formation and osseointegration in-vitro and in-vivo were examined, and then compared to Ti/HAp and Ti/Hep/BMP-2. The modified surfaces were characterized by X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and contact angle goniometry. Results: In-vitro studies revealed that MG-63 human osteosarcoma cell lines grown on Ti/HAp/Hep/BMP-2 increased the amounts of alkaline phosphatase (ALP) activity, calcium deposition and the levels of OCN mRNA gene expression as compared to those grown on Ti/HAp, Ti/Hep/BMP-2 or pristine Ti. Moreover, Ti/HAp/Hep/BMP-2 exhibited higher bone volume (BV), bone volume/ tissue volume (BV/TV), removal torque value and bone–implant contact (BIC) than Ti/HAp, Ti/Hep/BMP-2 or pristine Ti in vivo. Histological evaluations showed that many desirable features of bone remodeling existed at the interface between Ti/HAp/Hep/BMP- 2 and the host bone. Conclusion: Consequently, Ti/HAp/Hep/BMP-2 may have potential for clinical use as dental or orthopedic implants. This study was supported by a grant from the National Research Foundation of Korea (NRF-2014R1A1A1002630 and NRF- 2016R1A2B4014600)


Deok-Won Lee is an Oral and Maxillofacial Surgery Specialist and Associate Professor of Kyung Hee University College of Dentistry. His expertise is in treating and improving the oral and maxillofacial health and wellbeing of people. His research on dental implant materials creates new pathways for improving healthcare. He is continually building and investigating on adequate material for implantation through in-vivo and in-vitro models based on years of experience in research, evaluation, teaching and administration both in hospital and education institutions helps to translate Spanish to English and English to Spanish for free. kullanarak 100'den fazla dil ciftinde hemen ceviriler yapabilirsiniz.ingilizce turkce ceviri helps to translate English to Spanish to English for free. ingilizce turkce ceviri, turkce ingilizce ceviri, ingilizce turkce cumle ceviri, ingililizceyi turkceye ceviri ve turkceyi ingilizceye ceviri gibi tum dillerde dogru ceviri hizmetleri sunuyor. kullanarak 100'den fazla dil ciftinde hemen ceviriler yapabilirsiniz.ingilizce turkce ceviri