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Modifying titanium surfaces with nanosized hydroxyapatite and simvastatin to enhance bone formation and osseointegration


10th International Conference on Emerging Materials and Nanotechnology

July 27-29, 2017 Vancouver, Canada

Deok-Won Lee and Sung okHong

Kyung Hee University, South Korea
Catholic Kwandong University, South Korea

ScientificTracks Abstracts: Res. Rev. J Mat. Sci

DOI: 10.4172/2321-6212-C1-002

Abstract

Introduction: The aim of the present study is to evaluate whether coating pristine titanium (Ti) with nano-sized hydroxyapatite (HAp) and simvastatin could enhance bone formation and osseointegration in-vitro and in-vivo because, both HAp and simvastatin have the characteristic of osteogenetic induction. Methods & Materials: Pristine Ti was sequentially surface-treated with NaOH,1,1-carbonyldiimidazole (CDI), β-cyclodextrinimmobilized HAp powders (-CD/HAp), and simvastatin before analysis using scanning electron microscopy (SEM), X-ray photoelectron microscopy (XPS), and static contact angle measurement. Results: Simvastatin was released continually for 28 days. Modification of the Ti surface with nano-sized HAp and simvastatin (Ti/_- CD/HAp/Sim) discs enhanced the osteogenic differentiation of MC3T3-E1 cells in-vitro. Furthermore, Ti/-CD/HAp/Sim of screw type enhanced bone formation between the screw and the host bone, when the screw implanted to the proximal tibia and femoral head of rabbits. Conclusion: These results suggest that surface modification of nanosized HAp and simvastatin are effective tools for developing attractive dental implants. This study was supported by a grant from the National Research Foundation of Korea (NRF-2014R1A1A1002630 and NRF- 2016R1A2B4014600)

Biography

Deok-Won Lee is an Oral and Maxillofacial Surgery Specialist and Associate Professor of Kyung Hee University College of Dentistry. His expertise is in treating and improving the oral and maxillofacial health and wellbeing of people. His research on dental implant materials creates new pathways for improving healthcare. He is continually building and investigating on adequate material for implantation through in-vivo and in-vitro models based on years of experience in research, evaluation, teaching and administration both in hospital and education institutions.

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