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Self-assembled pectin-conjugated multi-arm-polyethylene glycol nanoparticles loading dihydroartemisinin for anticancer combination therapy

14th International Conference and Exhibition on Materials Science and Engineering

November 13-15, 2017 | Las Vegas, USA

Yanxue Liu

Beijing Forestry University, P. R. China

Posters & Accepted Abstracts: Res. Rev. J Mat. Sci

DOI: 10.4172/2321-6212-C1-012


Single-drug therapy for cancer is greatly hampered by its poor water-solubility, difficulties in controlling and predicting the drug release, and non-specific delivery to the target tissue that limited to the clinical application. In order to overcome these limitations, a novel self-assembled nanoparticle platform based on pectin-multi-arm-polyethylene glycol-dihydroartemisinin conjugate (PecMultiarm-PEG-DHA) was first presented. This conjugate was synthesized by introducing hydrophobic drugs dihydroartemisinin to hydrophilic polymer molecules eight-arm polyethylene glycol, and then was linked to pectin via ester linkages. Moreover, another anticancer drug hydroxycamptothecin (HCPT) was encapsulated into the self-assembled nanoparticles (Pec-Multiarm-PEG-DHA/ HCPT NPs). The obtained nanoparticles possessed appropriate size (~ 85 nm), high drug-loaded efficiency (~9.12 wt% DHA), encapsulation efficiency (~ 12.11 wt% HCPT), good stability and pH-dependent. The time-dependent cytotoxic of the Pec-MultiarmPEG-DHA/HCPT NPs was only 4% 4T1 cell and 2% MCF-1 cell survived after 72 h. Pec-Multiarm-PEG-DHA/HCPT NPs exhibited a higher cytotoxicity, longer blood retention time of free drug (8.0-fold DHA, 7.4-fold HCPT) and more effective cellular uptake than free drugs. 4T1 tumor-bearing mice treated with the nanoparticles also showed a 90.6% survival advantage in comparison with 15.5% free DHA and14.1% free HCPT. In addition, it is clearly an elaborate certification that nanoparticles could reduce the risk of hypersensitivity reactions substantially. Therefore, Pec-Multiarm-PEG-DHA/HCPT NPs is a promising potential for anticancer combination therapy. helps to translate Spanish to English and English to Spanish for free. kullanarak 100'den fazla dil ciftinde hemen ceviriler yapabilirsiniz.ingilizce turkce ceviri helps to translate English to Spanish to English for free. ingilizce turkce ceviri, turkce ingilizce ceviri, ingilizce turkce cumle ceviri, ingililizceyi turkceye ceviri ve turkceyi ingilizceye ceviri gibi tum dillerde dogru ceviri hizmetleri sunuyor. kullanarak 100'den fazla dil ciftinde hemen ceviriler yapabilirsiniz.ingilizce turkce ceviri