Review Article Open Access

A Review of Tumour Initiating Cells in Veterinary Oncology and Potential Implications in Canine Transmissible Venereal Tumours.

Abstract

The canine transmissible venereal tumour (CTVT) is a transplantable neoplasia considered an allograft. However, information about the origin and carcinogenesis process is scarcely known. Currently, some neoplasms are believed to arise from tumour-initiating cells (TIC’s) classically described in human myeloid leukemia. TVT intrinsic characteristics provide evidence of a possible TIC’s participation in carcinogenesis process of this malignancy. In this review, we highlight CTVT as a cancer stem cell model and describe the four main TIC markers commonly used to enrich tumour initiating cells in canine and human tumours.

Fabrizio Grandi, Helio Amante Miot, Bruno Cogliati, Noeme Sousa Rocha

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