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conferenceseries
.com
RRJOMS | Volume 5 | Issue 4 | July, 2017
July 27-29, 2017 Vancouver, Canada
10
th
International Conference on
Emerging Materials and Nanotechnology
Modifying titanium surfaces with nanosized hydroxyapatite and simvastatin to enhance bone formation
and osseointegration
Deok-Won Lee
1
and
Sung okHong
2
1
Kyung Hee University, South Korea
2
Catholic Kwandong University, South Korea
Introduction:
The aim of the present study is to evaluate whether coating pristine titanium (Ti) with nano-sized hydroxyapatite
(HAp) and simvastatin could enhance bone formation and osseointegration
in-vitro
and
in-vivo
because, both HAp and simvastatin
have the characteristic of osteogenetic induction.
Methods & Materials:
Pristine Ti was sequentially surface-treated with NaOH,1,1-carbonyldiimidazole (CDI), β-cyclodextrin-
immobilized HAp powders (-CD/HAp), and simvastatin before analysis using scanning electron microscopy (SEM), X-ray
photoelectron microscopy (XPS), and static contact angle measurement.
Results:
Simvastatin was released continually for 28 days. Modification of the Ti surface with nano-sized HAp and simvastatin (Ti/_-
CD/HAp/Sim) discs enhanced the osteogenic differentiation of MC3T3-E1 cells
in-vitro
. Furthermore, Ti/-CD/HAp/Sim of screw
type enhanced bone formation between the screw and the host bone, when the screw implanted to the proximal tibia and femoral
head of rabbits.
Conclusion:
These results suggest that surface modification of nanosized HAp and simvastatin are effective tools for developing
attractive dental implants.
This study was supported by a grant from the National Research Foundation of Korea (NRF-2014R1A1A1002630 and NRF-
2016R1A2B4014600)
Biography
Deok-Won Lee is an Oral and Maxillofacial Surgery Specialist and Associate Professor of Kyung Hee University College of Dentistry. His expertise is in treating
and improving the oral and maxillofacial health and wellbeing of people. His research on dental implant materials creates new pathways for improving healthcare.
He is continually building and investigating on adequate material for implantation through
in-vivo
and
in-vitro
models based on years of experience in research,
evaluation, teaching and administration both in hospital and education institutions.
verycutebear@hanmail.netDeok-Won Lee et al., Res. Rev. J Mat. Sci. 2017
DOI: 10.4172/2321-6212-C1-002