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Research Article Open Access

Development and Evaluation of Novel Co-processed Excipients for the Formulation of Tablets

Abstract

Co-processed excipients were prepared by precipitation method and melt granulation method. Co-processing is the way that new excipients coming to the market without undergoing rigorous safety testing of completely new chemical. It can be defined as combining two or more established excipients by an appropriate process. Co-processing of excipients could lead to formation of excipients with superior properties compared to simple physical mixtures of their components. The main aim of co-processing is to obtain product with an added value related to the ratio. Chitosan:Syloid XDP 3150 represents a potentially useful superdisintegrant in many pharmaceutical applications. Chitosan-Ozokerite wax represents a potentially useful floating time.The developed excipients were evaluated for compressibility index (Carr’s index), Hausner’ratio and Bulk density or Tapped density in comparison with physical mixture of excipients. The Bulk density and Tapped density was found to be (0.5 to 0.6) which indicate good flow in comparison to physical mixture of excipients due to granule formulation, Carr’s index in therange of the (49.2) and Hausner’ratio in the range of the (1.125).

In the present work we investigated co-processing Excipients were cop (C:S), chitosan and syloid XDP 3150, in weight ratios of 1:4 (w/w) and produced by direct mixing Differential Scanning Calorimetry (DSC), Fourier-Transform InfraRed (FT-IR), X-Ray Powder Diffraction (XRPD) and Scanning Electron Microscopy (SEM) techniques were used to characterize Cop-C:S and Cop- C:O , in addition to characterization of its powder and immediate release and controlled release dosage form.

Fast dissolving and Floating tablets of Metronidazole were prepared using the above co-processed excipients and evaluated for pre-compression and post–compression parameters. Among the tablets prepared, the co-processed Excipients Cop-(C:S), Cop-(C:O) at different ratio.

Kabir G Ghorphade

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