Review Article Open Access

Iron Overload and Chelation Strategies Effects on Cardiac Arrhythmia in Beta-Thalassemia Major

Abstract

Thalassemia is the name of a category of genetically inherited blood disorder passed down through families where the body produces an irregular type of hemoglobin, the protein that carries oxygen in red blood cells. This contributes to premature red blood cell death, leading to anemia. In addition, iron overload causes a threat to vital organs such as the liver and heart. Similarly, organs are affected by iron overload differently. Regular transfusion diagnosis, chelation therapy, bone marrow transplantation and medicine to reduce the accumulation of transfusion iron approximately 1.5% of the world's population are β-thalassemia heterozygotes; there is a high prevalence of populations from the Mediterranean basin to the Pacific Islands across the Middle East, the Indian Subcontinent, Southeast Asia, and Melanesia. Iron chelation agents solve problems of excess iron.

Ajay Kumar Singh*

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