Phytochemicals having Tubulin Inhibiting Properties for Cancer Treatment
In this review, the general mechanism of anti-tubulin agents has been summarized used for cancer treatment. Cancer is one of the most problematic ailments that do not have an ideal cure till date, but several phytoconstituents are found to be promising for the treatment of cancer by interfering with the normal cell cycle/mitosis in the cancerous cells. The plant having tubulin inhibiting properties are discussed and their binding domains are presented. The mechanism of action is based on destabilizing the tubulin protein which is important for the cell cycle. Plants from diverse sources were found to be effective in arresting the cell cycle and hence limiting the cancer growth with the least possible adverse effects.
Mohd Riyaz Beg, Shital Ghodinde