ISSN: 2322-0066

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article Open Access

Synthesis, Characterization, Docking and Antimicrobial Evaluation of Novel Compounds of 2-Phenoxy-1,3,2-Benzodioxaphosphole-2- Oxide-Oxo Azetidin and Pyrazol-5-One-Mannich Bases

Abstract

The synthetic route of new mannich bases of 4-(3-chloro-1-(2-oxido-2-(4- substituted phenoxy) [d] dioxaphosphole-5-yl)-4-oxoazetidin-2-yl)-1- (morpholinomethyl)-3-(tri fluoromethyl)-1H-pyrazole-5(4H)-one(8a-f) was depicted in scheme:1. The mannich bases (8a-f) were prepared by condensation reaction between 4-(3-chloro-1-(3,4–dihydroxyphenyl)-4- oxaazetidin-2-yl)-1-(morpholinomethyl)-3-(trifluoromethyl)-1H-pyrazol-5(4H)- one(6) and 4-Substituted-PhenylPhosphorodichlori date (7a-f). The synthon was obtained by hydrolysis of 4-(3-chloro-1-(3,4-dimethoxyphenyl)-4-oxo azetidin-2-yl)-1-(morpholinomethyl)-3-(trifluoromethyl)-1H-pyrazol-5-(4H)- one(5). The synthon was obtained by condensation reaction between 4- (((3,4-dimethoxyphenyl)imino)methyl)-1-(morpholinomethyl)-3-(trifluoro methyl)-1H-pyrazol-5-(4H)-one(4) and chloroacetyl chloride. The synthon was obtained by Mannic reaction between 4-(((3,4-dimethoxy phenyl)imino)methyl)-3-(trifluoromethyl)-1-1H-pyrazol-5-(4H)-one(3) with formaldehyde and morpholine. The synthon was obtained by condensation between 5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-4-carbaldehyde and 3-4-dimethoxy aniline. The structures of newly synthesized compounds (8a-f) were established by IR, 1HNMR, 13C-NMR, 31P-NMR, Mass spectral studies and Elemental analysis.

Madhavi Devarakonda*, B.Saritha, Y.N.Spoorthy and L.K.Ravindranath

To read the full article Download Full Article

https://maltcasino.fun/https://pinbahis.fun/https://onwin.direct/https://130betebet.com/https://detectivestripes.com/

paper.io

agar io

wormax io